Development of a Non-Invasive Prognostic Test for Graves Orbitopathy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07472062

Acronym

GoPro

Enrollment

Registered

2026-03-16

Start date

2023-05-13

Completion date

2026-12-31

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graves Orbitopathy, Hyperthyroidism

Brief summary

The aim of this research project is to develop a non-invasive, simple, robust, and sensitive prognostic test that can identify hyperthyroidism patients who are at risk of developing Graves' Orbitopathy. This phase of the study is a research phase in which we analyze blood samples and tear fluid using standard laboratory equipment and software. The aim is to identify biomarkers that can detect patients at risk of developing Graves' Orbitopathy. Offering more personalized advice, treatment, and follow-up could potentially prevent the clinical consequences or limit their severity.

Interventions

OTHERSchirmer's test

Collection of tears with Schirmer's test

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* healthy control OR diagnosis of hyperthyroidism OR diagnosis of Graves' Orbitopathy

Exclusion criteria

* \<18 y/o

Design outcomes

Primary

Measure	Time frame	Description
Biomarkers found in tears collected at Baseline	Baseline	During a one-day study visit (Baseline visit), tears will be collected from all study participants via a Schirmer's test.

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026