Role of High-Frequency Oscillations on Scalp EEG in Identifying Epileptogenic Activity in Patients With Epilepsy and Healthy Controls

Evaluation of High-Frequency Oscillations Detected by a Novel Signal Analysis Algorithm on Scalp Electroencephalography for Differentiating Patients With Epilepsy From Healthy Controls

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07470931

Enrollment

Registered

2026-03-13

Start date

2023-03-01

Completion date

2023-09-30

Last updated

2026-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsies

Brief summary

This observational case-control study aims to evaluate whether high-frequency oscillations (HFOs) detected on scalp electroencephalography (EEG) can differentiate patients with epilepsy from healthy controls. A signal-processing algorithm was developed to identify HFO activity in scalp EEG recordings, with particular focus on ripple (80-250 Hz) and fast ripple (250-500 Hz) frequency bands. Scalp EEG recordings obtained from patients with epilepsy and healthy controls are analyzed after preprocessing and filtering steps. The main outcome is the mean residence time of HFO-related activity above a predefined threshold in the ripple and fast ripple bands. The study investigates whether this noninvasive EEG-based approach may provide a useful biomarker for epilepsy diagnosis.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Inclusion Criteria for Epilepsy Group Adults diagnosed with epilepsy Availability of routine awake scalp EEG recording suitable for analysis EEG recorded with the study protocol and technical specifications Inclusion Criteria for Control Group Adults without epilepsy Referred for EEG evaluation in the context of syncope differential diagnosis Scalp EEG recording suitable for analysis

Exclusion criteria

* EEG recordings with inadequate technical quality or excessive artifact burden preventing HFO analysis Individuals not meeting study group definitions

Design outcomes

Primary

Measure	Time frame	Description
Mean residence time of high-frequency oscillation activity in the ripple band (80-250 Hz) on scalp EEG	At the time of EEG assessment / baseline	The mean duration for which the ripple-band signal envelope remains above the predefined threshold, compared between epilepsy and control groups.

Countries

Turkey (Türkiye)

Outcome results