Bupivacaine Alone vs Bupivacaine With Tramadol in Local Anesthesia Procedures

Efficacy of Bupivacaine Alone and Bupivacaine With Tramadol in Local Anesthesia Procedures

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07469826

Enrollment

100

Registered

2026-03-13

Start date

2022-10-10

Completion date

2023-05-10

Last updated

2026-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Pain, Acute

Keywords

Bupivacaine, Tramadol, Post operative pain

Brief summary

This study looked at two different medicines used during local anesthesia to control pain after surgery. Investigators compared bupivacaine alone with bupivacaine mixed with tramadol. Both medicines are commonly used to numb the surgical area and reduce pain. The investigators included 100 adult patients who had minor surgeries under local anesthesia. Half received only bupivacaine, and the other half received bupivacaine combined with tramadol. After surgery, patients were asked to rate their pain at 4, 8, and 24 hours. The results showed that patients who received bupivacaine with tramadol felt less pain, especially at 24 hours after surgery, compared to those who received bupivacaine alone. In simple words: Adding tramadol to bupivacaine helps reduce pain better than bupivacaine alone. This method may help patients recover faster, feel more comfortable, and need fewer pain medicines after surgery.

Interventions

DRUGTramadol

A single dose of 1 mg/kg tramadol at the surgical site

DRUGBupivacaine

Single dose 0.5 ml/kg of 0.25% Bupivacaine at surgical site

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* All patients undergoing elective procedure under local anesthesia * Either gender. * Age 18-60 years.

Exclusion criteria

* Procedures Under general anesthesia. * Diabetic patients, assessed by history and clinically and HbA1c \>6.5% * Patients with metastatic disease, assessed by history, clinically and by imaging. * Patients who are I/V opioid abusers will be excluded.

Design outcomes

Primary

Measure	Time frame	Description
Mean postoperative pain score	Patients were monitored for 24 hours immediately following the completion of the surgical procedure	Mean postoperative pain score using the visual analog scale at 4,8 and 24 hours postoperatively. Visual Analog Scale (VAS) is a 10-cm horizontal line ranging from 0 (no pain) to 10 (worst imaginable pain). Patients will mark the point representing their pain intensity. Scores will be recorded at predetermined postoperative intervals.

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 14, 2026