Egg Donation, Infertility Assisted Reproductive Technology
Conditions
Brief summary
Since the 2021 revision of French bioethics laws, access to assisted reproductive technologies (ART) has expanded, leading to a significant increase in gamete donation requests. In this context, oocyte donation remains a limited resource, with marked disparities between centers and persistent donor shortages. At the Assisted Reproductive Technology Center of Nancy University Hospital, more than fifty women have initiated an oocyte donation process since the implementation of the new legislation. However, not all candidates complete the donation pathway, and clinical and organizational outcomes have not yet been formally evaluated. This retrospective observational study will evaluate the oocyte donation pathway at the Assisted Reproductive Technology Center of Nancy University Hospital. The study population will include all women who attended a biological consultation for primary or secondary oocyte donation from the implementation of the new Bioethics laws until December 31, 2025 (study period). Baseline clinical and biological characteristics of donor candidates will be described, including age, body mass index, anti-Müllerian hormone level, and antral follicle count. The proportion of donor candidates undergoing oocyte retrieval and the time interval between the first biological consultation and oocyte retrieval will be assessed. Biological and clinical outcomes will also be analyzed, including the number of oocytes retrieved, the number of mature oocytes (metaphase II) obtained, fertilization rate following in vitro fertilization, clinical pregnancy rate per embryo transfer, and live birth rate. Results will be compared with national data reported by the French Biomedicine Agency in order to evaluate the activity and outcomes of the center and to identify potential areas for organizational and clinical improvement in the oocyte donation pathway. The overall objective is to optimize donor management and improve access to oocyte donation for recipient patients.
Interventions
None listed
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
No
Inclusion criteria
* All women who attended a biological consultation for primary or secondary oocyte donation at Nancy University Hospital during the study period.
Exclusion criteria
* Absence of biological consultation for oocyte donation during the study period ; * Insufficient or missing medical data ; * Documented opposition to data use for research purposes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of donor candidates undergoing oocyte retrieval | From the first biological consultation until oocyte retrieval, assessed up to 12 months | Proportion of patients who underwent oocyte retrieval following ovarian stimulation among all donor candidates who attended a biological consultation for oocyte donation at Nancy University Hospital during the study period. The outcome will be reported as a percentage (number of oocyte retrieval procedures divided by the total number of donor candidates evaluated). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean number of oocytes retrieved per oocyte retrieval procedure | At the time of oocyte retrieval procedure, approximately 14-16 days after the start of ovarian stimulation | Total number of oocytes collected during transvaginal oocyte retrieval divided by the number of retrieval procedures performed. |
| Mean time from first biological consultation to oocyte retrieval | From the first biological consultation until oocyte retrieval, assessed up to 12 months | Mean time interval between the first biological consultation for oocyte donation and the oocyte retrieval procedure among donor candidates who completed ovarian stimulation and underwent oocyte retrieval. The time interval will be calculated in months. |
| Median number of mature oocytes (metaphase II) retrieved per donor | At the time of oocyte retrieval procedure, approximately 14-16 days after the start of ovarian stimulation | Median number of mature oocytes at the metaphase II stage obtained per oocyte retrieval procedure. Only oocytes classified as metaphase II at the time of assessment in the embryology laboratory will be included in the calculation. |
| Fertilization rate following in vitro fertilization or intracytoplasmic sperm injection | 1 day after fertilization | Proportion of normally fertilized oocytes (two pronuclei) among the total number of inseminated or injected mature oocytes. |
| Clinical pregnancy rate per embryo transfer | From embryo transfer until confirmation of clinical pregnancy by ultrasound, assessed up to 8 weeks after embryo transfer | Proportion of embryo transfer cycles resulting in a clinical pregnancy defined as the presence of an intrauterine gestational sac with fetal heartbeat detected by ultrasound. |
| Live birth rate following oocyte donation cycles | From embryo transfer until delivery, assessed up to 41 weeks of gestation | Proportion of embryo transfer cycles resulting in at least one live birth. |
Countries
France
Contacts
CONTACTCaroline AIMONE-VIANNA, PHD Medicine
Outcome results
None listed