Invasive Ventilation
Conditions
Brief summary
The goal of this investigation is to examine the effect of nasal airflow in invasively ventilated adult patients following planned surgery. The main questions it aims to answer are: * Does the investigational device produce an effect measured by EEG? * Are there differences in effect with modified airflow states?
Interventions
DEVICETUI-1
Provision of airflow to the nasal cavity by F\&P Tui at baseline rate
DEVICETUI-2
Provision of airflow to the nasal cavity by F\&P Tui at modified rate
Sponsors
Fisher and Paykel Healthcare
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults \>18 years of age * Receiving sedation via propofol and fentanyl * Undergoing surgical procedure with planned post-operative invasive ventilation
Exclusion criteria
* Pre-existing neurological injury or condition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Power spectral density of EEG | Before and 10 minutes after initiation of nasal airflow | Mean PSD will be calculated across beta, alpha, delta and gamma frequency bands |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Power spectral density of EEG between interventions | 10 minutes after initiation of nasal airflow | Mean PSD will be calculated across beta, alpha, delta and gamma frequency bands and compared between TUI-1 and TUI-2 |
| Coherence | Before and 10 minutes after initiation of nasal airflow | Inter-regional EEG coherence will be quantified as a measure of functional connectivity |
Countries
New Zealand
Contacts
CONTACTKelly Gradon
Outcome results
None listed