Skin Rejuvenation, Laser
Conditions
Brief summary
Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis, including decreased collagen characterized by dermal thinning, as well as alterations in skin appearance such as laxity and wrinkles. Laser therapy is one of the treatment modalities for skin rejuvenation, aiming to induce neocollagenesis and collagen remodeling, resulting in dermal thickening and improvement in skin appearance. Fractional CO₂ laser is an ablative laser considered the gold standard therapy for skin rejuvenation, whereas Long Pulsed (LP) Nd:YAG 1064 nm is a nonablative laser that is also used for skin rejuvenation. To date, there have been no studies evaluating the comparative effectiveness between fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation. Therefore, research comparing the effectiveness of fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation is needed, assessed based on dermal thickness, skin elasticity, wrinkles, and Global Aesthetic Improvement Scale scores.
Interventions
PROCEDUREFractional CO₂ laser
Fractional CO₂ laser was applied to one randomized side of the face in a split-face design for skin rejuvenation. Treatments were performed three times at one-month intervals. The laser delivers fractional ablative microthermal zones to stimulate dermal remodeling and collagen production. Treatment parameters were adjusted according to skin type and clinical indication.
PROCEDURELong-pulsed 1064-nm Nd:YAG laser
Long-pulsed 1064-nm Nd:YAG laser was applied to the contralateral randomized side of the face in a split-face design for skin rejuvenation. Treatments were performed three times at one-month intervals. The laser delivers non-ablative dermal heating to stimulate collagen remodeling and improve skin texture and elasticity.
Sponsors
Universitas Padjadjaran
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 59 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and female patients with skin aging classified as Glogau scale II-III * Age 30-59 years.
Exclusion criteria
* Pregnant or breastfeeding women. * Active smokers. * Individuals with high levels of sun exposure. * History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months. * Use of oral isotretinoin within the past six months. * Use of topical retinoids or their derivatives, topical vitamin C, or other collagen-stimulating and skin-rejuvenating agents within the past two weeks. * Use of oral vitamin C, collagen-stimulating supplements, antioxidants, or hormone therapy with skin-rejuvenating effects within the past one month. * Presence of active facial skin inflammation. * History of keloid formation. * History of allergy to topical lidocaine anesthesia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dermal Thickness | From enrollment to the end of treatment at 20 weeks | Dermal thickness was assessed based on the two-dimensional area of the hyperechoic band that appears brighter than the epidermis on ultrasonography assessment. |
| Skin Elasticity | From enrollment to the end of treatment at 20 weeks | Skin elasticity was defined as the ability of the skin to return to its original shape after deformation caused by mechanical traction. It was measured using a skin elasticity meter, and the R (recovery) value was assessed at 8 evaluation points on the face. |
| Wrinkles | From enrollment to the end of treatment at 20 weeks | Lines or folds formed on the skin surface as a result of mechanical stress, skin dehydration, or repetitive muscular activity, and were evaluated using a facial skin analyzer |
| Global Aesthetic Improvement Scale Scores | From enrollment to the end of treatment at 20 weeks | A 5-point rating scale (1-5) used to measure the degree of aesthetic improvement in patients following a procedure. |
Countries
Indonesia
Contacts
CONTACTAhmad R Ganiem, M.D., Ph.D
CONTACTKartika Ruchiatan, M.D.
PRINCIPAL_INVESTIGATORKartika Ruchiatan, M.D.
Faculty of Medicine Universitas Padjadjaran Bandung
Outcome results
None listed