Atrial Fibrillation (AF), CABG, Visceral Adipose Tissue
Conditions
Keywords
Atrial Fibrillation (AF), Visceral Adipose Tissue, CABG
Brief summary
Obesity has become a major public health problem in both developed and developing countries, with a continuous increase particularly since the 1980s. Moreover, it is a well-established metabolic risk factor for diabetes mellitus, hypertension, and various types of cancer, as well as cardiovascular diseases such as heart failure and coronary artery disease. Body mass index (BMI) is calculated by dividing body weight in kilograms by the square of height in meters and is widely used as an indicator of obesity. However, BMI does not quantitatively reflect body fat distribution and fails to account for components such as skeletal muscle and bone mass. Therefore, interest in assessing body fat distribution has increased, and in recent years, studies evaluating the correlation between anthropometric, biochemical, and anatomical measurements and clinical outcomes have become more frequent. In particular, it is acknowledged that abdominal obesity cannot be accurately represented by BMI alone and is primarily associated with visceral adipose tissue (VAT). The aim of this study is to evaluate the association between preoperative visceral and subcutaneous adipose tissue measurements (VAT and SAT), assessed by ultrasonography in patients scheduled for open-heart surgery, and the development of postoperative atrial fibrillation.
Interventions
OTHERPostoperative AF Group
In patients undergoing coronary artery bypass graft surgery, ultrasound-guided measurements of visceral and subcutaneous adipose tissue will be performed preoperatively. The relationship between adipose tissue thickness and the development of postoperative atrial fibrillation will be evaluated by comparing patients who develop AF with those who do not.
OTHERNon-AF Group
In patients undergoing coronary artery bypass graft surgery, ultrasound-guided measurements of visceral and subcutaneous adipose tissue will be performed preoperatively. The relationship between adipose tissue thickness and the development of postoperative atrial fibrillation will be evaluated by comparing patients who develop AF with those who do not.
Sponsors
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Elective isolated coronary artery bypass graft surgery (on-pump) * Age ≥18 years, planned prospectively in 300 patients
Exclusion criteria
* Patients requiring urgent or emergency surgery * Off-pump coronary artery bypass graft surgery * Surgeries other than isolated coronary artery bypass graft * Patients in whom abdominal ultrasound measurement cannot be performed (e.g., due to severe deformity, wounds, edema) * Active malignancy * eGFR \<30 mL/min * Advanced-stage chronic obstructive pulmonary disease (COPD) * Preoperative atrial fibrillation or atrial flutter * Patients who do not provide written informed consent for the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of visceral adipose tissue thickness on postoperative atrial fibrillation | Within 7 days after coronary artery bypass graft surgery or until hospital discharge | Preoperative ultrasound-guided measurement of visceral adipose tissue thickness will be performed. The association between visceral fat thickness and the development of postoperative atrial fibrillation will be evaluated. |
Contacts
CONTACTOZGE PEKSEN KIZILISIK
Outcome results
None listed