Anesthesia
Conditions
Keywords
bupivacaine, dexmetomedine, spinal anesthesia, cessarian delivery
Brief summary
Cesarean section (CS) is one of the most frequently performed surgical procedures globally, with an increasing demand for safe and effective anesthesia techniques. Regional anesthesia, particularly intrathecal anesthesia, has become the method of choice for elective cesarean deliveries.The most commonly used local anesthetic for intrathecal anesthesia is bupivacaine.Recent studies have focused on adjunctive agents to enhance the efficacy of local anesthetics.
Interventions
DRUGBupivacaine
patient will receive intra-thecal hyperbaric bupivacaine 11 mg(2.2 ml) of 0.5% bupivacaine, with 0.5 ml of normal saline in total volume 2.5 ml.
patient will receive 9 mg (1.8 ml) of 0. 5% bupivacaine, with 5 μg of DEX in 0.5ml of normal saline in total volume 2.5 ml.
Sponsors
Benha University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* (1) Full-term pregnant women undergoing elective cesarean section under spinal anesthesia. (2) Age: 20 \~ 35 years. (3) ASA physical status II \~ III
Exclusion criteria
1. Multiple pregnancies. 2. Cardiovascular disease(e.g., pre-eclampsia and hypertension). 3. Serious hepatic dysfunction (Child-Pugh class C). 4. serious renal dysfunction (undergoing dialysis before surgery). 5. History of alcohol or opioid addiction. 6. Contraindication to spinal anesthesia. 7. Refusing to sign informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the duration of sensory block | after anesthesia up to 12 hours postoperatively | time taken from intrathecal injection to sensory regression to S1 dermatome. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the onset time of sensory block | during 30 minutes after intrathecal injection | time taken from intrathecal injection to the maternal feeling of lower extremities temperature increment or numbness |
| the onset time of motor block | during 30 minutes after intrathecal injection | time taken from intrathecal injection to MBS \> 1 |
| The recovery quality of parturients | 24 hours post-operatively | ObsQoR-11, score from 0 to 10 in each term, where 0 = strongly agree and 10 = strongly disagree, the higher of the score, the higher of recovery quality |
Countries
Egypt
Contacts
CONTACTfatma ahmed abdelfatah, MD
Outcome results
None listed