Extubation Time, Myelomeningocele, Neonatal
Conditions
Keywords
Myelomeningocele, Neonate, Operating Room Extubation, NICU Length of Stay
Brief summary
Meningomyelocele is one of the most common neural tube defects requiring surgical repair in the neonatal period. Postoperative respiratory complications and the need for prolonged mechanical ventilation are important causes of morbidity in these patients. The timing of extubation may influence postoperative respiratory outcomes and the duration of neonatal intensive care unit (NICU) stay. This retrospective cohort study aims to evaluate the impact of operating room extubation on postoperative outcomes in neonates undergoing meningomyelocele repair at Gaziantep City Hospital. Clinical, laboratory, and perioperative data will be obtained from hospital records. Postoperative mechanical ventilation requirement, duration of ventilation, NICU length of stay, and perioperative laboratory changes will be compared between neonates extubated in the operating room and those extubated in the intensive care unit.
Interventions
None listed
Sponsors
Gaziantep City Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Days to 28 Days
Healthy volunteers
No
Inclusion criteria
* Neonates undergoing surgical repair of meningomyelocele * Surgery performed under general anesthesia * Age ≤ 28 days at the time of surgery * Postoperative follow-up in the neonatal intensive care unit (NICU) * Availability of complete perioperative clinical and laboratory data
Exclusion criteria
* Preoperative respiratory distress requiring invasive or non-invasive ventilatory support * Major congenital anomalies or severe comorbidities (e.g., complex congenital heart disease, severe pulmonary disease, chromosomal abnormalities) * Neonates with poor postnatal adaptation (5-minute Apgar score \< 7) * Preoperative hemodynamic instability * Severe prematurity-related respiratory morbidity * Prolonged mechanical ventilation due to causes unrelated to meningomyelocele surgery * Incomplete or missing perioperative medical records
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Mechanical Ventilation Requirement | Within the first 48 hours after surgery | Requirement for invasive mechanical ventilation after meningomyelocele repair in neonates. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Lactate Level | Baseline (preoperative) and 24 hours after surgery | Difference between preoperative and postoperative blood lactate levels. |
| Length of NICU Stay | From surgery until discharge from the neonatal intensive care unit, up to 30 days | Duration of stay in the neonatal intensive care unit following meningomyelocele repair. |
| Change in Blood pH | Preoperative vs postoperative 24 hours | Difference between preoperative and postoperative blood pH values. |
Countries
Turkey (Türkiye)
Contacts
PRINCIPAL_INVESTIGATORRecep Karakaşoğlu, MD
Gaziantep City Hospital
STUDY_CHAIRSinan Ünsal, MD
Gaziantep City Hospital
STUDY_DIRECTORBurak C. Balık, MD
Gaziantep City Hospital
Outcome results
None listed