Simulation-Based Team Training for Management of Local Anesthetic Systemic Toxicity (LAST) in Non-Anesthesiologist Surgical Residents

Evaluation of the Effectiveness of a Local Anesthetic Systemic Toxicity (LAST) Knowledge Training Program for Non-Anesthesiologist Surgical Residents

Status

Enrolling by invitation

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07463274

Acronym

LAST

Enrollment

102

Registered

2026-03-11

Start date

2025-09-15

Completion date

2026-02-28

Last updated

2026-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Education, Questionnaires

Keywords

Local anesthetic, Questionnaires, Regional anesthesia, Team

Brief summary

This randomized controlled trial evaluates the effectiveness of a simulation-based multidisciplinary team training program on the management of Local Anesthetic Systemic Toxicity (LAST) among non-anesthesiologist surgical residents. Guided by Kirkpatrick's evaluation model, the study investigates improvements in knowledge, technical and non-technical skills, and the retention of these competencies one month after training

Detailed description

Local Anesthetic Systemic Toxicity (LAST) is a rare but potentially life-threatening complication of regional anesthesia. Advances in ultrasound-guided blocks have reduced its incidence, yet LAST remains a major concern due to severe cardiovascular and neurological risks. The American Society of Regional Anesthesia and Pain Medicine (ASRA) recommends early lipid emulsion therapy and emphasizes proper training. Simulation-based multidisciplinary training provides a dynamic and immersive experience, improving both technical and behavioral skills. This trial applies Kirkpatrick's four-level model (reaction, learning, behavior, results) to assess the training program. Primary endpoint: improvement in knowledge test scores. Secondary endpoints: OSCE performance, satisfaction, and key performance indicators related to simulated LAST management.

Interventions

BEHAVIORALEducation

Local Anesthetic Systemic Toxicity (LAST); Simulation-based Education; Perioperative Training

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

SINGLE (Outcomes Assessor)

Intervention model description

Randomized, Parallel Assignment, Prospective, Assessor-blinded

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

1. Surgical residents (General Surgery, Orthopedics, Obstetrics \& Gynecology, Dentistry) on active rotation at Selçuk University Faculty of Medicine. 2. Voluntary participation with written informed consent. 3. No prior comprehensive LAST training in the last 12 months.

Exclusion criteria

1. Prior comprehensive LAST training or instructor experience in the last 12 months. 2. Anesthesiology residents or specialists. 3. Unable to complete follow-up due to rotation change or leave. 4. Declining or withdrawing consent.

Design outcomes

Primary

Measure	Time frame	Description
Knowledge improvement (Learning outcome)	Baseline (Day 0) to immediately post-training.	Local Anesthetic Systemic Toxicity (LAST) Knowledge Level and Awareness Test Change in 25-item multiple-choice test score (Δ = post-test - pre-test) Scoring: 0-25. It is accepted that as the score obtained for the test increases, the level of knowledge about the subject increases.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 12, 2026