Implantation Failure
Conditions
Brief summary
This study aims to evaluate whether fire-needle combined with regular acupuncture improves pregnancy outcomes in patients with recurrent implantation failure (RIF), compared to no or regular acupuncture. A retrospective cohort study was conducted at a university-affiliated hospital. One hundred RIF patients undergoing embryo transfer between July 2024 and June 2025 were assigned to three groups: a non-acupuncture group, a regular acupuncture group, and a fire needle combination group (receiving both fire needle and regular acupuncture). Key outcome measures, including the β-hCG positive rate, clinical pregnancy rate (CPR), and miscarriage rate (MR), were compared among the three groups.
Interventions
OTHERno acupuncture
no acupuncture
DEVICEregular acupuncture
Regular acupuncture
DEVICEFire needle combination group
fire needle combination group (receiving both fire needle and regular acupuncture)
Sponsors
Huazhong University of Science and Technology
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* (1)18 ≤age ≤40 years; (2) ≥2 previous failures of high-quality embryo transfer without clinical pregnancy
Exclusion criteria
* (1) preimplantation genetic testing cycles; (2) use of donor oocytes; (3) missing key data on treatment or outcome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| β-hCG-positive pregnancy | 1 year | Test for hCG in the blood day 14 post-transfer |
| Clinical pregnancy | 1 year | ultrasonographic detection of an intrauterine gestational sac following embryo transfer |
| Miscarriage | 1 year | defined as spontaneous pregnancy loss occurring after ultrasound-confirmed clinical pregnancy |
Countries
China
Outcome results
None listed