Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV

Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV (SPISE)

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07461350

Acronym

SPISE

Enrollment

400

Registered

2026-03-10

Start date

2026-08-05

Completion date

2030-03-31

Last updated

2026-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV (Human Immunodeficiency Virus)

Keywords

HIV, cardiac MRI, stimulant use

Brief summary

This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardiac MRI.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

\- Participants with and without HIV enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) Atlanta, Baltimore, Bronx, and San Francisco study sites

Exclusion criteria

* Standard contraindications to MRI * claustrophobia, * metal implants, * large body size (weight \>350 lbs or abdominal sagittal diameter \>70 cm), * pregnancy) * Gadolinium risk * severe or uncontrolled asthma, * visit day eGFR\<45 ml/min/1.73 m2; * poor venous access * pregnancy or lactation

Design outcomes

Primary

Measure	Time frame	Description
Cardiac MRI	Visit 1, up to 2 hours	CMR assessments to provide detailed myocardial characterization (e.g. diffuse inflammation (nT1), myocardial fibrosis (ECV), and myocardial scar assessed using LGE)

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORPhyllis Tien, MD

University of California, San Francisco

PRINCIPAL_INVESTIGATORElise Riley, PhD