Compare Between the Effect of CGF and PRF on Revascularization of Immature Roots of the Mandibular Permanent First Molar

Concentrated Growth Factor Versus Platelets-rich Fibrin in Revascularization of Immature Necrotic Mandibular First Permanent Molar.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07460869

Enrollment

Registered

2026-03-10

Start date

2025-01-10

Completion date

2027-07-10

Last updated

2026-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Revascularization of Immature Young Permenant Teeth

Keywords

CGF and PRF

Brief summary

in this study investigators do revascularization technique to promote root growth of immature mandibular first permanent molar by using CGF and PRF from blood sample of patients

Detailed description

children 6-8 yrs were selected for this study because the roots of mandibular first permanent molar is not completed. then access cavity is opened, irrigation protocol is applied, intracanal medication is applied and the cavity is sealed with temporary filling. after three weeks blood sample is obtained from patients to get CGF and PRF membranes. temporary filling is removed . intracanal medication is removed, over instrumentation is done to get some intracanal blood the wait tell blood clot is formed then CGF or PRF is applied on the clot the bio dentine is applied and cavity is sealed with composite restoration

Interventions

BIOLOGICALRevascularization/Conservative management

Compare the effect of CGF and PRF in the revascularization of immature mandibular first permanent molar using bio-dentine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Intervention model description

parallel randomized controlled study

Eligibility

Sex/Gender

ALL

Age

6 Years to 8 Years

Healthy volunteers

Yes

Inclusion criteria

* Children with immature necrotic lower fitrst permanent molar. * No history of repeated pathosis or cellulitis. * Patients accept the treatment modality. * Patient-free from systemic, allergic or genetic problems.

Exclusion criteria

* Tooth mobility. * Teeth with non-restorable crowns. * Children with facial cellulitis * Children with draining fistula * Children with a history of recurrent preapical pathosis

Design outcomes

Primary

Measure	Time frame	Description
root growth	18 months	change root length

Countries

Egypt

Contacts

PRINCIPAL_INVESTIGATORAhmed elheeny, professor of Pediatric and Com

unaffilliaed

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 11, 2026