ProActive Athlete Heart Program: Proposal for Cardiac Risk Screening in Former High-Intensity Athletes

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07460583

Enrollment

100

Registered

2026-03-10

Start date

2026-04-28

Completion date

2026-12-31

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Atherosclerosis Due to Calcified Coronary Lesion

Brief summary

AI-Guided Coronary CT Angiography Screening in Former High-Intensity Athletes

Detailed description

A prospective, interventional, single-center study to determine the prevalence and characteristics (burden, composition, risk features) of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

Interventions

DEVICECoronary CTA

The Coronary CTA will be performed for each participant. These images will be analyzed using AI-software to assess plaque quantification and an ischemia analysis, if necessary.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

* Former professional or collegiate high-intensity athletes (e.g., NFL alumni, Division I athletes, or equivalent competitive-level participants). * Age ≥30 years

Exclusion criteria

* eGFR \<40 mL/min/1.73 m² * Known iodinated contrast allergy * Weight \>450 lbs. (scanner table limit) * Inability to hold breath \>10 seconds * Uncontrolled arrhythmia * Contraindication to beta-blocker, Calcium Channel Blockers and nitroglycerin * Taking part in another research study that has not given their permission to participate in this one * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of Coronary Atherosclerosis	At CCTA assessment	The primary outcome is to determine the prevalence of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.
Coronary Atherosclerosis Characteristics	At CCTA Assessment	Determine the characteristics (burden, composition, risk features) of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

Secondary

Measure	Time frame	Description
Plaque Burden	Day of CCTA and biomarker collection	The secondary outcome is to correlate plaque burden with biomarkers (Lipid panel, HbA1c).

Countries

United States

Contacts

CONTACTBonnie Ostergren

bonnie.ostergren@bswhealth.org469-814-4181

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026