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Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone

Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07460076
Acronym
TUBERO-IMPLANT
Enrollment
15
Registered
2026-03-10
Start date
2026-01-01
Completion date
2026-11-01
Last updated
2026-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alveolar Bone Loss, Esthetic Zone Implant Rehabilitation

Keywords

Immediate Implant Placement, Maxillary Tuberosity Graft, Autogenous Bone Graft, Dental Implant, Pink Esthetic Score

Brief summary

Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help reconstruct the buccal bone plate during immediate implant placement. This prospective case series aims to evaluate the clinical and esthetic outcomes of immediate implant placement combined with autogenous maxillary tuberosity graft in the esthetic zone. The primary outcomes include buccal bone thickness measured on cone-beam computed tomography (CBCT), facial soft tissue thickness measured clinically, and the pink esthetic score (PES) after implant restoration.

Detailed description

Immediate implant placement has become a widely accepted treatment modality in the esthetic zone. However, the presence of buccal bone defects following tooth extraction may negatively affect peri-implant tissue stability and esthetic outcomes. Autogenous bone graft harvested from the maxillary tuberosity has been proposed as a reliable grafting material due to its corticocancellous structure and high osteogenic potential. This prospective interventional case series aims to evaluate the effectiveness of autogenous maxillary tuberosity graft used in conjunction with immediate implant placement in the esthetic zone. Patients requiring extraction and implant placement in the maxillary esthetic region will be treated with immediate implant placement and augmentation using a two-layer autogenous graft harvested from the maxillary tuberosity, consisting of cortical bone and connective tissue. Clinical and radiographic outcomes will be assessed during follow-up. Buccal bone thickness will be evaluated using cone-beam computed tomography (CBCT). Facial soft tissue thickness will be measured clinically. Esthetic outcomes will be assessed using the pink esthetic score (PES) following definitive prosthetic restoration. The results of this study are expected to provide clinical evidence regarding the effectiveness of maxillary tuberosity autogenous grafts for improving peri-implant tissue stability and esthetic outcomes in immediate implant placement.

Interventions

PROCEDUREImmediate Implant Placement With Maxillary Tuberosity Autogenous Graft

Immediate implant placement in the maxillary esthetic zone combined with autogenous bone graft harvested from the maxillary tuberosity. The graft is used to reconstruct the buccal bone plate and improve peri-implant tissue stability and esthetic outcomes.

Sponsors

University of Medicine and Pharmacy at Ho Chi Minh City
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

Single-arm prospective case series evaluating immediate implant placement with autogenous maxillary tuberosity graft in the esthetic zone.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adults aged 18 years or older * Patients requiring single implant placement in the maxillary esthetic zone * Indication for immediate implant placement following tooth extraction * Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft * Adequate oral hygiene and ability to maintain postoperative care * Willingness to participate in the study and provide informed consent

Exclusion criteria

* Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases * History of radiotherapy in the head and neck region * Active periodontal disease or untreated oral infection * Heavy smoking (more than 10 cigarettes per day) * Pregnancy or lactation * Severe parafunctional habits * Insufficient bone volume preventing implant placement with the planned protocol * Patients unable to attend follow-up visits

Design outcomes

Primary

MeasureTime frameDescription
Buccal Bone Thickness6 months after implant placementBuccal bone thickness around the implant measured on cone-beam computed tomography (CBCT) in the mid-facial aspect of the implant site.

Secondary

MeasureTime frameDescription
Facial Soft Tissue Thickness6 months after implant placementFacial peri-implant soft tissue thickness measured clinically at the mid-facial aspect of the implant site.

Countries

Vietnam

Contacts

CONTACTDuy Anh Tran, DDS
tranduyanhump17@gmail.com+84 868324216

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 11, 2026