Changes in Scalp Condition After Using a Moisturizer: a Prospective Clinical Trial Using Artificial Intelligence

Changes in Scalp Condition After Using a Moisturizer Containing Celastrol and Cichorium Intybus Root Extract: a Prospective Clinical Trial Using Artificial Intelligence

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07459023

Acronym

scalp

Enrollment

Registered

2026-03-09

Start date

2025-07-01

Completion date

2025-12-31

Last updated

2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dandruff, Seborrhoeic Dermatitis of the Scalp

Keywords

scalp discomfort, scalp erythema, scalp dryness, scalp scaling, scalp pruritus

Brief summary

The goal of this clinical trial is to evaluate whether a scalp moisturizer containing celastrol and Cichorium intybus root extract can improve scalp condition in adults aged 19 years or older who require scalp moisturization due to dryness, scaling, erythema, or dandruff. The main questions it aims to answer are: Does once-daily application of the study moisturizer improve scalp condition from baseline to week 4, as assessed by SPI-AI (Scalp Photographic Index-Artificial Intelligence)? Does the moisturizer improve scalp biophysical parameters (erythema index, stratum corneum hydration, and transepidermal water loss) and patient-reported symptom severity over the 4-week treatment period? Participants will: Apply the study moisturizer once daily at bedtime to dry scalp for 4 weeks and rinse it off the following morning using their usual shampoo. Attend study visits at baseline (week 0), week 2, and week 4 for scalp imaging, biophysical measurements, symptom questionnaires, adherence assessment, and safety monitoring.

Interventions

OTHERDucray Kertyol P.S.O. Concentrate Cream, Ducray Laboratory, France

participants applied the moisturizer once daily to the entire scalp at bedtime

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age ≥19 years * Presence of scalp erythema, dryness, scaling, or dandruff requiring scalp moisturization

Exclusion criteria

* Active infectious scalp dermatoses * Use of topical or systemic therapies affecting scalp status within 4 weeks prior to enrollment or during the study period * Inability to comply with the study protocol

Design outcomes

Primary

Measure	Time frame	Description
SPI-AI	4week	Scalp Photographic Index with artificial intelligence

Secondary

Measure	Time frame	Description
SPI-AI	2week	Scalp Photographic Index with artificial intelligence
Biophysical parameter	2week	erythema index (arbitrary unit)
Patient-reported outcome	2 week	visual analog scale (0-10) : higher is worse

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026