Infertility Assisted Reproductive Technology
Conditions
Keywords
return rate, cryopreservation, family building
Brief summary
This monocentric retrospective cohort study aims to investigate reproductive behavior and subsequent family-building outcomes in couples who achieved a first live birth through assisted reproductive technology (ART) at a university-affiliated fertility center in Italy. All couples obtaining a first live birth between January 2010 and December 2020 will be included and followed until December 2024. The primary objective is to evaluate the rate of return for further ART treatment after the first live birth. Secondary objectives include assessing cumulative live birth rate (CLBR) for the second and third live birth. Associations between return behavior and clinical factors, including maternal age, presence of cryopreserved oocytes or embryos, and treatment characteristics, will be analyzed.
Interventions
None listed
Sponsors
Istituto Clinico Humanitas
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 43 Years
Healthy volunteers
No
Inclusion criteria
* Copules underwent ART treatment at the Humanitas Fertility Center (Rozzano, Milan) * Copules achieved a first clinical pregnancy resulting from ART between January 2010 and December 2020 * heterosexual couples in which the maternal age was between 18 and 43 years old
Exclusion criteria
* Couples who did not meet the inclusion criteria * ART cycles involving preimplantation genetic testing for aneuploidy (PGT-A) * Use of donor gametes (oocyte or sperm donation)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Return rate of couples who had achieved a first pregnancy and returned to pursue a second child. | From January 2010 to December 2024 | Analysis of the return rate of couples who had already achieved a first pregnancy and pursued a second child, with a comprehensive evaluation of the clinical, demographic, and treatment-related factors that may influence their likelihood of returning for additional ART attempts. This analysis aims to identify which characteristics are associated with a higher or lower probability of continuing their family-building journey after the initial live birth. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cumulative live birth rate of couples who had already achieved a first live birth and attempted to conceive a second child | From January 2010 to December 2024 | Analysis of the cumulative live birth rate of couples who had already achieved a first live birth and pursued a second child through subsequent ART attempts, with a comprehensive evaluation of the clinical, demographic, and treatment-related factors that may influence their probability of achieving an additional live birth. This analysis aims to identify which characteristics are associated with higher or lower chances of successfully obtaining a second live birth after the initial one |
Outcome results
None listed