Major Depressive Diorder
Conditions
Keywords
Major Depressive, selective serotonin, magnesium, combination therapy symptoms
Brief summary
Role of Magnesium in Depressive Disorder
Detailed description
Because of the significant role that magnesium serves in mood regulation, the goal of this study is to evaluate the impact of starting the therapy of major depressive disorder with a combination of SSRI and Mg, as well as SSRI alone.
Interventions
DRUGUse of magnesium with SSRI
Impact of combination of SSRI and Magnesium in Major Depressive Disorder
DRUGSSRI
Only SSRI will be given
Sponsors
University of Child Health Sciences and Children's Hospital, Lahore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All patients of above 18 years diagnosed with DSM who had MDD and receiving SSRI alone and SSRI plus magnesium.
Exclusion criteria
Individuals who recently underwent treatment with electroconvulsive therapy, have a history of epilepsy or other severe neurological problems, have experienced a head injury, are cognitively impaired, and have comorbid conditions such as liver, renal, cardiovascular, neurological, or endocrine, or respiratory problems, or are pregnant or nursing mothers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in severity of depressive symptoms | Four Weeks | Change in severity of depressive symptoms, measured by the difference in mean scores on the Beck Depression Inventory-II (BDI-II) from baseline to 4 weeks post-intervention |
Countries
Pakistan
Contacts
STUDY_CHAIRAtif Najum, MBBS, FCPS
CMH Multan
Outcome results
None listed