Alopecia Areata(AA)
Conditions
Keywords
Alopecia areata, Glucocorticoid, polymorphism
Brief summary
Alopecia areata is an autoimmune, non-scarring hair loss disorder with multifactorial pathogenesis. The glucocorticoid receptor gene (NR3C1) plays an essential role in immune regulation and inflammatory response. The rs41423247 polymorphism (BclI) may influence glucocorticoid sensitivity and disease activity. This study aims to investigate the association between NR3C1 rs41423247 polymorphism and susceptibility to alopecia areata and to evaluate its correlation with disease severity using the Severity of Alopecia Tool (SALT) score.
Interventions
None listed
Sponsors
Benha University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
(Cases): * Clinically diagnosed alopecia areata * Age ≥ 18 years * Both sexes * Willingness to participate and provide informed consent Inclusion Criteria (Controls): * Apparently healthy individuals * No history of autoimmune disease * Age- and sex-matched to cases * Provided informed consent
Exclusion criteria
* Presence of other autoimmune or inflammatory diseases * Current systemic immunosuppressive therapy * Pregnancy or lactation * Refusal to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Distribution of NR3C1 rs41423247 Genotypes and Alleles | Baseline | Comparison of genotype and allele frequencies of NR3C1 rs41423247 polymorphism between alopecia areata patients and healthy controls. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association Between NR3C1 rs41423247 Polymorphism and Disease Severity | Baseline | Correlation between NR3C1 rs41423247 genotypes and Severity of Alopecia Tool (SALT) score in patients with alopecia areata. |
Countries
Egypt
Outcome results
None listed