Cirrhosis
Conditions
Brief summary
To investigate the association between lactate-mediated alterations in the gut microbiota and disease progression in patients with liver cirrhosis; and to examine the correlations of lactate levels among serum, fecal, and tissue samples in patients with liver cirrhosis.
Interventions
observational study, no intervention
Sponsors
Zhujiang Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
\- 1. Healthy individuals without a history of liver disease or related underlying disorders; or patients diagnosed with liver cirrhosis and its complications based on imaging and/or liver biopsy, with a history of chronic liver disease for more than 6 months. Etiologies include chronic hepatitis B virus infection, nonalcoholic fatty liver disease, and alcoholic liver disease, among others. 2\. Willing to participate in this study and able to provide written informed consent.
Exclusion criteria
* 1\. A history of severe organic diseases involving the liver, gastrointestinal tract, kidneys, or other organ systems; malignant tumors; or autoimmune diseases. 2\. Patients with acute infection or inflammatory diseases within the past 1 month. 3\. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota composition | baseline |
| Lactate level | baseline |
Countries
China
Contacts
CONTACTYi Xu
STUDY_DIRECTORXiaolong He
Southern Medical University, China
Outcome results
None listed