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Effects of Gesture Plus Verbal Treatment (GVT) in Cantonese Speakers With Aphasia

Contrasting Effects of Verbal Treatment and Gesture Plus Verbal Treatment for Word Retrieval in Cantonese Speakers With Aphasia

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07455162
Enrollment
90
Registered
2026-03-06
Start date
2025-04-01
Completion date
2028-09-01
Last updated
2026-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aphasia, Gestures

Keywords

Aphasia, Gesture, Rehabilitation

Brief summary

This research aims to explore the relative efficacy of Verbal-only and GVT on naming difficulty in Cantonese-speaking people with aphasia (PWA). The primary research question in this study is: "For Cantonese-speaking people with aphasia, what are the relative effects of verbal treatment compared to gesture plus verbal treatment (GVT) on verbal and gesture naming at different levels?" People with aphasia will be engaged in a repeated measures experimental design. Participants will be engaged in two phases of training. In the first phase, participants will be assigned to receive verbal-only treatment. To minimize and prevent the carry-over effects caused by the first intervention, a one-month washout period will be implemented before the start of the second phase. After a washout period, participants will switch to GVT in the second phase.

Interventions

BEHAVIORALVerbal treatment

This study will involve the following naming interventions: 1) Semantic Features Analysis, 2) Modified Ortho-phonological cueing therapy and Phonological Component Analysis, and 3) Repetition with Cueing Hierarchy.

BEHAVIORALGesture plus verbal treatment

This study will involve the following interventions: 1\) Combined Semantic and Gesture treatment, 2) Combined Phonological and Gesture treatment, and 3) Combined Repetition and Gesture treatment.

Sponsors

Hong Kong University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Intervention model description

Participants will be engaged in two phases of training. In the first phase, participants will be assigned to receive verbal-only treatment. To minimize and prevent the carry-over effects caused by the first intervention, a one-month washout period will be implemented before the start of the second phase. After a washout period, participants will switch to GVT in the second phase.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Diagnosed with aphasia * Demonstrate Word finding Difficulty (WFD) * Able to repeat single words * Normal (or corrected) vision and hearing * Aphasia resulting from a unilateral left hemisphere stroke * Premorbidly fluent in spoken Cantonese * Without significant cognitive impairments * Chronic aphasia resulting from a unilateral left hemisphere stroke

Exclusion criteria

* A history of other neurological disorders * With the above moderate to severe or severe motor speech impairment * With moderate to severe apraxia of speech * With very mild or very severe aphasia

Design outcomes

Primary

MeasureTime frameDescription
Changes in the scores of the Naming ProbesFrom enrollment to the end of treatment at 4 weeksThe treatment effects on naming will be assessed through verbal naming and gesture production using the black and white drawing naming task. Responses will be counted as correct if they can be identified by the rater as the target word in verbal naming and convey the depicted concept through gesture production, even if the articulation or hand and arm movements are slightly distorted.

Secondary

MeasureTime frameDescription
Changes in the scores of the Cantonese Aphasia BatteryFrom enrollment to the end of treatment at 4 weeksThe Cantonese Aphasia Battery was conducted to evaluate improvements in various linguistic measures (e.g., question comprehension, step commands, repetition, etc.). The minimum and maximum values are 0 and 100, respectively, with higher scores indicating a better outcome.
Changes in the scores of the Comprehensive Aphasia TestFrom enrollment to the end of treatment at 4 weeksThe Comprehensive Aphasia Test will be conducted to evaluate improvements in various cognitive and linguistic measures (e.g., semantic memory, word fluency, auditory comprehension, etc.). There are different subtests in the assessment, with a minimum value of 0, and maximum values ranging from 70 to 130, with higher scores indicating a better outcome.
Changes in the scores of the Cantonese Boston Naming TestFrom enrollment to the end of treatment at 4 weeksThe Cantonese Boston Naming Test will be conducted to evaluate the generalization effects on naming ability. The minimum and maximum values are 0 and 30, respectively, with higher scores indicating a better outcome.
Changes in the number of main concepts and gestures in discourse production tasksFrom enrollment to the end of treatment at 4 weeksDiscourse samples were collected from participants through various monologues. The discourse elicitation tasks included Main concept analysis, procedural (Ham and Egg Sandwich), narrative (Telling of the story "Tortoise and Hare"), and personal narrative (Sharing of an important event). This will help in assessing their word retrieval abilities at both the sentence and discourse levels, and their verbal and non-verbal communication skills in realistic contexts. Regarding discourse assessment, all samples will be video recorded using a camera. After that, the samples will undergo discourse analysis based on Chinese Linguistics Communication Measures, where conversational speech will be transcribed, and the linguistic index will be calculated and compared. Finally, the number of various types of gestures will also be computed and compared.
Changes in the scores of the Functional Communication questionnaireFrom enrollment to the end of treatment at 4 weeksImprovements in functional communication will be evaluated using the Functional Assessment of Communication Skills questionnaire. There are different subtests in the assessment, with minimum values of 0, and maximum values ranging from 35 to 147, with higher scores indicating a better outcome.

Countries

Hong Kong

Contacts

CONTACTAnnie Zhiyao Hu
annie920@connect.hku.hk852-6068-8312
STUDY_CHAIRAnthony Pak Hin Professor Kong

The University of Hong Kong

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 12, 2026