Association of TLR7 Gene rs3853839 Polymorphism With Disease Severity in Alopecia Areata: A Case-Control Study

Association Between Toll Like Receptor- 7 Gene Polymorphism and Alopecia Areata

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07454876

Acronym

TLR7-AA

Enrollment

120

Registered

2026-03-06

Start date

2022-12-01

Completion date

2023-12-12

Last updated

2026-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alopecia Areata, TLRs

Keywords

Alopecia Areata, TLR7, rs3853839

Brief summary

Alopecia areata is an autoimmune, non-scarring hair loss disorder characterized by variable clinical severity. Toll-like receptor 7 (TLR7) plays a key role in innate immune activation and autoimmune responses. The rs3853839 polymorphism of the TLR7 gene has been implicated in immune-mediated diseases. This study aims to evaluate the association between TLR7 rs3853839 polymorphism and susceptibility to alopecia areata, and to assess its correlation with disease severity measured by the Severity of Alopecia Tool (SALT) score. \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

(Cases): * Clinical diagnosis of alopecia areata * Age ≥ 18 years * Both genders * Provision of written informed consent Inclusion Criteria (Controls): * Apparently healthy individuals * No personal or family history of autoimmune disease * Age- and sex-matched to patient group * Provision of written informed consent

Exclusion criteria

* Presence of other autoimmune or inflammatory disorders * Current systemic immunosuppressive therapy * Pregnancy or lactation * Refusal to participate

Design outcomes

Primary

Measure	Time frame	Description
Genotype and Allele Frequency Distribution of TLR7 rs3853839	Baseline	Comparison of genotype and allele frequencies of TLR7 rs3853839 polymorphism between alopecia areata patients and healthy controls.

Secondary

Measure	Time frame	Description
Association Between TLR7 rs3853839 Polymorphism and Disease Severity	Baseline	Evaluation of the correlation between TLR7 rs3853839 genotypes and Severity of Alopecia Tool (SALT) score among alopecia areata patients.

Countries

Egypt

Outcome results