Effect of Sodium Chloride 5% Solution as an Adjuvant Treatment With Antimicrobial Therapy in the Treatment of Bacterial Infectious Keratitis

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07452588

Acronym

keratitis

Enrollment

Registered

2026-03-05

Start date

2026-02-01

Completion date

2027-02-01

Last updated

2026-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adjuvant Treatment Bacterial Infectious Keratitis, Infectious Keratitis, Sodium Chloride 5% Solution

Keywords

Bacterial infectious keratitis, Sodiunchloride5%

Brief summary

This study aims to detect the effect of sodium chloride 5% solution as an adjuvant treatment with antimicrobial therapy in treatment of bacterial infectious keratits and to assess whether NaCl 5% accelerates epithelial healing, improves microbial eradication, and enhances visual outcomes in bacterial infectious keratitis.

Detailed description

Prospective randomized control study to detect the effect of sodium chloride 5% solution as an adjuvant treatment with antimicrobial therapy in treatment of bacterial infectious keratits and to assess whether NaCl 5% accelerates epithelial healing, improves microbial eradication, and enhances visual outcomes in bacterial infectious keratitis.Data study will include two groups classified as follow : the first group will include treatment of microbial keratitis by antibiotic with sodium chloride 5% , the second group will include treatment by antibiotic only

Interventions

DRUGSodium chloride 5% solution

Use Sodium chloride 5% solution with usual anti microbial drugs

DRUGquinolones

Use of usual topical anti microbial treatment only

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

IncluInclusion Criteria * Age ≥ 18 years. * Clinically diagnosed bacterial infectious keratitis * Positive corneal scraping or strong clinical suspicion of bacterial cause. * Ability to provide informed consent and attend follow-up visits

Exclusion criteria

* • Fungal, viral, or acanthamoeba keratitis. * Recent (\<7 days) topical corticosteroid use. * Corneal perforation or impending perforation. * History of hypersensitivity to study agents. * Systemic immunocompromised state (uncontrolled diabetes, Human immune defecinicy virus). * Poor compliance expected with follow-up.

Design outcomes

Primary

Measure	Time frame	Description
Control of infection	6 months	Improvement of manifestation according to rate of healing

Contacts

CONTACTNancy Safwat Kaldas, Specialist

nansy_safwat_post@med.sohag.edu.eg01200933440

CONTACTAmr Mounir Mohamed, Assistant professor

01005026170

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 6, 2026