Bariatric Surgery, Diabete Type 2, Obesity
Conditions
Brief summary
To explore influencing factors of diabetes remission and recovery of other complications after bariatric surgery. We design a multicenter study including respective cohort and prorespective cohort of obese patients treated with bariatric surgery or non-bariatric surgery，and collect clinical parameters and laboratory indicators.
Interventions
PROCEDUREBariatric surgery
Laparoscopic sleeve gastrectomy or laparoscopic gastric bypass based on β-cell function
OTHERNon-surgical threapy
Diet management，exercise，metformin，GLP-1RA and other drugs which can lose weight.
Sponsors
China-Japan Friendship Hospital
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
12 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Age range from 12 to 75 years, 2. BMI (Body Mass Index) ≥ 25.0 kg/m2,
Exclusion criteria
1. Type 1 diabetes, 2. Severe liver or kidney disease (eGFR \< 30 ml/min), malignant tumors, endocrine disorders such as thyroid or Cushing's syndrome, acute coronary syndrome, uncontrolled heart failure, pregnancy or lactation, pancreatitis, 3. Contraindications to other surgeries or medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total weight loss | 1st, 3rd, 6th and 12th month after intervention, respectively. |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Average blood glucose from continuous glucose monitoring | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Postprandial 2-hour blood glucose | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| HbA1c | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Waist circumference and hip circumference | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Medication status | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Quality of life score | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| AHI | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| GERDQ Score | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Urinary microalbumin | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Serum creatinine | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| TC | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| TG | 1st, 3rd, 6th and 12th month after intervention, respectively. |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORHua Meng
China-Japan Friendship Hospital
Outcome results
None listed