The Impact of Extreme Physical Exertion on Cardiovascular System, The Impact of Extreme Physical Exertion on Glucose, The Impact of Extreme Physical Exertion on Health, The Impact of Extreme Physical Exertion on Joints and Muscles, The Impact of Extreme Physical Exertion on Kidney Function and Water-electrolytes Balance, The Impact of Extreme Physical Exertion on Neurological System, The Impact of Extreme Physical Exertion on Respiratory System
Conditions
Brief summary
The "Supermarathon 2025" study was designed as a prospective, interdisciplinary field study to assess the impact of extreme physical exertion, such as a 100-kilometer ultramarathon, on the health of individuals aged ≥ 45 years. A multi-module strategy was employed, including assessment of metabolic, circulatory, respiratory, neurological, dental, psychological, and musculoskeletal functions.
Interventions
DIAGNOSTIC_TESTBlood and urine analysis
Blood and urine analysis
Sponsors
Medical University of Gdansk
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
44 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 45 years * Planned completion of a 100 km race during a specific sporting event * Willingness to participate in all research procedures included in the project
Exclusion criteria
* Refusal to participate in the project * Occurrence of serious illnesses that may pose a risk to the athlete * Detection of significant changes in health status during the initial examination that may be associated with complications during exercise (participants were advised against participating in the race and were not included in the study group)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in blood and urine results | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | NT-proBNP in pg/ml |
| Troponin I | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Troponin I in ng/L |
| Glucose | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Glucose in mg/dl |
| Insulin | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Insulin in ulU/ml |
| Hemoglobin A1c | Blood samples were collected one day before the start | Hemoglobin A1c in % |
| Lipid profile | Blood samples were collected one day before the start | LDL cholesterol, HDL cholesterol, total cholesterol and Triglicerydes in mg/dl |
| Creatinine kinase | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Creatinine kinase in U/l |
| Uric acid | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Uric acid in mg/dl |
| Vitamine D3 | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Vitamine D3 in ng/ml |
| Serum iron | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | serum iron in ug/dl |
| Ferritin | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Ferritin in ng/ml |
| Creatinine | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Creatinine in mg/dl |
| Sodium | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Sodium in mmol/l |
| Potassium | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Potassium in mmol/l |
| C-reative protein | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | C-reractive protein in mg/l |
| Liver enzymes | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | alanine aminotransferase, aspartate aminotransferase in U/L |
| Bilirubin | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Bilirubin in mg/dl |
| Albumin | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. | Albumin in g/l |
| Cortisol in saline | Saline smaples were taken one day before the race and within one hour after finishing the race | Cortisol in saline in ug/dL |
| FSH and LH | Blood samples were collected one day before the start and within 1 hour after finishing the race | FSH and LH |
| Estradiol | Blood samples were collected one day before the start and within 1 hour after finishing the race | Estradiol in pg/ml |
| Testosterone | Blood samples were collected one day before the start and within 1 hour after finishing the race | Testosterone in ng/dl |
| SHGB | Blood samples were collected one day before the start and within 1 hour after finishing the race | SHGB in nmol/l |
| Cortisole and progestrone | Blood samples were collected one day before the start and within 1 hour after finishing the race | Cortisole and progestrone in ng/ml |
| Continuous glucose monitoring | Sensor was placed one day before the race and was measuring glucose for 14 days | continuous glucose monitoring using FS libre |
| Weight | Measurements were taken 1 day before and within 1 hour after finishing the race | Weight in kilograms |
| Height | Measurements were taken 1 day before the race | Height in cm |
| Body composition | Measurements have been made 1 day before the race and within 1 hour after finishing the race | Body composition using Tanita BC-545N - parameters in % |
| ECG | Measurements have been made 1 day before the race and within 1 hour after finishing the race | ECG measurements |
| Echocardiography | Measurements have been made 1 day before the race and within 1 hour after finishing the race | Echocardiography |
| ECG Holter | ECG Holter was connected 1 day before the race and was checking heart rate and ecg within following 14 days | ECG Holter |
| Neurological examination | Examination was performed 1 day before the race and within 1 hour after finishing the race | Neurological examination |
| Dental examination | Examination was performed 1 day before the race and within 1 hour after finishing the race | Dental examination |
| Ortophedic examination | Examination was performed 1 day before the race and within 1 hour after finishing the race | Ortophedic examination |
| Spirometry | Examination was performed 1 day before the race and within 1 hour after finishing the race | Spirometry |
| Psychological examination | Examination was performed 1 day before the race and within 1 hour after finishing the race | Psychological examination |
Countries
Poland
Outcome results
None listed