Impact of Anterior Clinoid Process Pneumatization on Optic Canal and Retinal Nerve Fiber Layer

Evaluation of the Effects of Anterior Clinoid Process Pneumatization on Optic Canal Morphometry and Retinal Nerve Fiber Layer Thickness Using Computed Tomography and Optical Coherence Tomography: A Retrospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07451080

Enrollment

100

Registered

2026-03-05

Start date

2025-08-01

Completion date

2026-02-01

Last updated

2026-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Clinoid Process Pneumatization, Optic Canal Morphometry, Retinal Nerve Fiber Layer Thickness

Keywords

Anterior Clinoid Process, Pneumatization, Optic Canal, Optic Canal Morphometry, Optical Coherence Tomography, Computed Tomography

Brief summary

This retrospective cohort study aims to evaluate the potential effects of anterior clinoid process (ACP) pneumatization on optic canal morphometry and retinal nerve fiber layer (RNFL) thickness. ACP pneumatization is an anatomical variation that may alter the morphology of the optic canal and potentially influence the optic nerve. Patients aged 18-65 years with available head and neck computed tomography (CT) imaging and optical coherence tomography (OCT) examinations between August 2018 and July 2025 will be retrospectively reviewed. Optic canal length and diameter will be measured using CT images, and RNFL thickness parameters will be obtained from OCT records. Measurements will be compared between patients with and without ACP pneumatization.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Adults aged 18 to 65 years. * Availability of head and neck computed tomography (CT) imaging in the hospital archive. * Availability of optical coherence tomography (OCT) examination records in the hospital archive. * CT and OCT examinations performed between August 2018 and July 2025.

Exclusion criteria

* Age \<18 years or \>65 years. History or evidence of diabetes mellitus. History or evidence of hypertension. Glaucoma. Any condition or diagnosis that may cause optic nerve pathology (e.g., optic neuritis, compressive optic neuropathy, optic atrophy, demyelinating disease affecting the optic nerve). Inadequate image quality or incomplete CT/OCT data preventing reliable measurements.

Design outcomes

Primary

Measure	Time frame	Description
Optic Canal Mean Diameter	Baseline (retrospective review of CT images obtained between August 2018 and July 2025)	Optic canal mean diameter measured on computed tomography (CT) images.
Retinal Nerve Fiber Layer (RNFL) Thickness	Baseline (retrospective review of OCT images obtained between August 2018 and July 2025)	Peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography (OCT).
Optic Canal Length	Baseline (retrospective review of CT images obtained between August 2018 and July 2025)	Optic canal length measured on computed tomography (CT) images.

Countries

Turkey (Türkiye)

Outcome results