Retrospective Analysis of Acute Pancreatitis After Percutaneous Mechanical Thrombectomy In Treatment Of Thrombotic Disorders

Retrospective Analysis of Acute Pancreatitis After Percutaneous Mechanical Thrombectomy In Treatment Of Thrombotic Disorders (The RATIO Study)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07450898

Enrollment

Registered

2026-03-05

Start date

2016-01-01

Completion date

2026-12-31

Last updated

2026-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pancreatitis (AP), Thrombotic Disorders

Keywords

Thrombectomy

Brief summary

Acute pancreatitis is a rare complication after percutaneous mechanical thrombectomy in treatment of thrombotic disorders. The objectives of this study include: (1) Determine the incidence and severity of acute pancreatitis after percutaneous mechanical thrombectomy; (2) Identify patient/procedural risk factors; (3) Evaluate clinical outcomes; (4) Develop a diagnosis and treatment pathway.

Detailed description

Percutaneous mechanical thrombectomy (PMT) has seen increasing utilization in the management of acute thrombotic events within both arterial and venous systems. The rheolytic thrombectomy such as AngioJet system employs hydrodynamic principles to disrupt and remove thrombus. The efficacy and safety have been demonstrated across various vascular diseases, including deep venous thrombosis (DVT), peripheral arterial occlusions, and dialysis access thrombosis, establishing PMT as a valuable minimally invasive therapeutic option. Acute pancreatitis is a serious inflammatory condition commonly associated with gallstones, alcohol consumption, hyperlipidemia, or metabolic disorders. Only isolated case reports have documented this complication following PMT. Despite the well-documented occurrence of other procedure-related adverse events, such as bradycardia, hemoglobinuria, and renal impairment, pancreatitis remains an exceptionally rare and under-recognized complication. The objectives of this study include: (1) Determine the incidence and severity of acute pancreatitis after percutaneous mechanical thrombectomy; (2) Identify patient/procedural risk factors; (3) Evaluate clinical outcomes; (4) Develop a diagnosis and treatment pathway.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients over 18 years old; * Patients with thrombotic peripheral vascular diseases treated by percutaneous mechanical thrombectomy; * Patients developed acute pancreatitis within 14 days after percutaneous mechanical thrombectomy; * Patients with written informed consent.

Exclusion criteria

* Patients with acute pancreatitis attributed to other confirmed causes; * Patients unable or unwilling to participate in the study.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of acute pancreatitis	Within 14 days	The incidence of acute pancreatitis within 14 days after mechanical thrombectomy for peripheral thromboembolic disease.

Secondary

Measure	Time frame	Description
Incidence of acute severe pancreatitis	Within 14 days	The incidence of acute severe pancreatitis within 14 days after mechanical thrombectomy for peripheral thromboembolic disease.

Countries

China

Contacts

CONTACTQihong Ni

niqihong1989@163.com15801900772

PRINCIPAL_INVESTIGATORQihong Ni

Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University

Outcome results