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How Personality Type Affects Pain and the Need for General Anesthesia in Patients Receiving an Arm Nerve Block for Wrist Fracture Surgery

The Effect of Affective Temperament on Block Success and Hemodynamics in Patients Undergoing Axillary Plexus Block for Distal Radius Fracture: A Prospective Observational Study.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07450768
Enrollment
46
Registered
2026-03-05
Start date
2023-03-15
Completion date
2024-03-15
Last updated
2026-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temperament, Trauma (Including Fractures)

Keywords

affective temperament, TEMPS-A, Axillary brachial plexus block, Conversion to general anesthesia, Postoperative pain

Brief summary

This study looked at whether a person's emotional personality type affects how they experience pain and how well a regional anesthesia technique works during arm surgery. We studied patients who underwent wrist or upper arm surgery using an axillary nerve block (a type of regional anesthesia that numbs the arm). Before surgery, patients completed a questionnaire measuring their emotional temperament, including anxious, depressive, cyclothymic, irritable, and other personality traits. We found that patients with an anxious personality type were more likely to need conversion to general anesthesia during surgery. They also reported higher pain scores after surgery. Patients with depressive traits also experienced higher pain levels. In contrast, some other temperament types reported lower pain levels. These findings suggest that emotional characteristics may influence how patients respond to anesthesia and pain after surgery. Understanding a patient's temperament before surgery may help doctors better plan anesthesia, provide additional support when needed, and improve overall comfort and safety. This research supports a more personalized approach to anesthesia care, taking into account not only physical health but also psychological factors.

Detailed description

This prospective observational study evaluates the association between affective temperament profiles and perioperative anesthetic outcomes in adult patients undergoing elective upper extremity surgery under ultrasound-guided axillary brachial plexus block. Affective temperament was assessed preoperatively using the validated TEMPS-A (Temperament Evaluation of Memphis, Pisa, Paris, and San Diego - Autoquestionnaire). Based on established scoring methodology, participants were categorized into depressive, anxious, cyclothymic, hyperthymic, irritable, or non-dominant temperament types. The instrument is grounded in Akiskal's affective temperament model, which conceptualizes temperament as a stable trait influencing stress reactivity, emotional processing, and physiological responses. All patients received a standardized anesthetic protocol. Ultrasound-guided axillary brachial plexus block was performed with identification of the radial, median, ulnar, and musculocutaneous nerves. A total of 20 mL of 0.25% bupivacaine was administered. Intravenous fentanyl (50 µg) was given prior to block placement. Intraoperative discomfort was managed with supplemental sedation. Conversion to general anesthesia was performed when regional anesthesia alone was insufficient to maintain surgical conditions. Block failure was defined as inability to complete the procedure using the regional technique alone. Hemodynamic parameters (systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate) were recorded at baseline and at 5-minute intervals during surgery. Postoperative pain intensity was measured using the Visual Analog Scale at predefined perioperative time points. Statistical analyses included correlation testing and multivariable modeling. LASSO regression was applied for variable selection and identification of predictors of increased postoperative pain scores. Ridge logistic regression was used to determine independent predictors of anesthesia escalation, accounting for multicollinearity among baseline hemodynamic variables and temperament types. This study explores whether stable affective traits influence regional anesthesia adequacy, intraoperative physiological responses, and postoperative pain perception, with the aim of informing individualized perioperative management strategies.

Interventions

None listed

Sponsors

Kirsehir Ahi Evran Universitesi
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age between 18 and 65 years * Scheduled for elective upper extremity surgery requiring axillary brachial plexus block * American Society of Anesthesiologists (ASA) physical status I-III * Ability to understand and complete the TEMPS-A questionnaire * Provision of written informed consent

Exclusion criteria

* Refusal to participate * Contraindication to regional anesthesia (e.g., local infection at injection site, coagulopathy) * Known allergy to local anesthetics (bupivacaine) * Cognitive impairment or inability to complete the temperament questionnaire * Severe psychiatric disorder requiring active treatment * Incomplete perioperative data or missing VAS assessments

Design outcomes

Primary

MeasureTime frameDescription
Anesthesia Escalation (Sedation and/or General Anesthesia)Intraoperative period (from block performance until completion of surgery)Proportion of patients who required escalation beyond axillary brachial plexus block, defined as the need for additional intravenous sedation and/or conversion to general anesthesia due to inadequate surgical anesthesia or patient discomfort.

Secondary

MeasureTime frameDescription
Postoperative Pain Intensity (VAS Score)Preoperative baseline, postoperative 3rd hour, 12th hour, and 24th hourPain intensity measured using the Visual Analog Scale (0-10), where 0 represents no pain and 10 represents worst imaginable pain.
Predictors of Anesthesia EscalationIntraoperative periodIdentification of independent predictors of conversion to general anesthesia using Ridge logistic regression analysis.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 6, 2026