Anastomotic Leak, Esophageal Malignant Neoplasm Primary
Conditions
Keywords
esophageal malignancy, esophagectomy, anastomotic leak, Memorial Sloan Kettering Cancer Center, 26-045
Brief summary
The main purpose of this study is to look at how often anastomotic leaks happen in participants who are at high risk of these leaks and are eligible to receive gastric preconditioning by percutaneous angioembolization before an esophagectomy.
Interventions
Eligible participants will undergo esophagectomy after preoperative gastric preconditioning by percutaneous angioembolization.
Sponsors
Study design
Eligibility
Inclusion criteria
* Documentation of Disease * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy. * Patients must also have risk factors for anastomotic leak: * Previous foregut or bariatric surgery (gastric sleeve or gastric bypass), but excluding fundoplication-only surgery OR * Salvage esophagectomy OR * Planned cervical anastomosis OR * Two or more comorbidities: * Diabetes, obesity, coronary artery disease, vascular disease (including celiac stricture or atherosclerosis, significant aortic disease, or any previous diagnosis of peripheral arterial disease), steroid use, hypertension, current or former smoker, renal insufficiency, and heart failure. * Definition of Disease * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy and risk factors for anastomotic leak, as described above. * Patients must be candidate and have agreed to receive gastric preconditioning procedure * Prior Treatment o There are no requirements with regard to prior treatment. * Age ≥ 18 * ECOG Performance Status of ≤ 2 (See Appendix I for performance status criteria)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of anastomotic leak | 1 year | Determine the incidence of anastomotic leak among participants with a high risk of esophageal leak who undergo esophagectomy after preoperative gastric preconditioning by percutaneous angioembolization. |
Countries
United States
Contacts
Memorial Sloan Kettering Cancer Center