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Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak

Gastric Preconditioning by Percutaneous Angioembolization Before Esophagectomy in Patients With a High Risk of Anastomotic Leak

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07449208
Enrollment
40
Registered
2026-03-04
Start date
2026-02-25
Completion date
2029-02-25
Last updated
2026-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anastomotic Leak, Esophageal Malignant Neoplasm Primary

Keywords

esophageal malignancy, esophagectomy, anastomotic leak, Memorial Sloan Kettering Cancer Center, 26-045

Brief summary

The main purpose of this study is to look at how often anastomotic leaks happen in participants who are at high risk of these leaks and are eligible to receive gastric preconditioning by percutaneous angioembolization before an esophagectomy.

Interventions

PROCEDUREEsophagectomy

Eligible participants will undergo esophagectomy after preoperative gastric preconditioning by percutaneous angioembolization.

Sponsors

Memorial Sloan Kettering Cancer Center
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Documentation of Disease * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy. * Patients must also have risk factors for anastomotic leak: * Previous foregut or bariatric surgery (gastric sleeve or gastric bypass), but excluding fundoplication-only surgery OR * Salvage esophagectomy OR * Planned cervical anastomosis OR * Two or more comorbidities: * Diabetes, obesity, coronary artery disease, vascular disease (including celiac stricture or atherosclerosis, significant aortic disease, or any previous diagnosis of peripheral arterial disease), steroid use, hypertension, current or former smoker, renal insufficiency, and heart failure. * Definition of Disease * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy and risk factors for anastomotic leak, as described above. * Patients must be candidate and have agreed to receive gastric preconditioning procedure * Prior Treatment o There are no requirements with regard to prior treatment. * Age ≥ 18 * ECOG Performance Status of ≤ 2 (See Appendix I for performance status criteria)

Design outcomes

Primary

MeasureTime frameDescription
Incidence of anastomotic leak1 yearDetermine the incidence of anastomotic leak among participants with a high risk of esophageal leak who undergo esophagectomy after preoperative gastric preconditioning by percutaneous angioembolization.

Countries

United States

Contacts

CONTACTDaniela Molena, MD
molenad@mskcc.org212-639-3870
CONTACTErnesto Santos Martin, MD
santosme@mskcc.org212-639-7327
PRINCIPAL_INVESTIGATORDaniela Molena, MD

Memorial Sloan Kettering Cancer Center

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 5, 2026