Lewy Body Disease With Mild Cognitive Impairment, Mild Cognitive Impairment (MCI) Amnestic, Parkinson's Disease With Mild Cognitive Impairment
Conditions
Keywords
Temporal Interference Stimulation, Functional Magnetic Resonance Imaging, Sentence Comprehension, Language Processing, Brain Connectivity, Striatum, Fronto-striatal Circuit, Mild Cognitive Impairment, Neurodegenerative Diseases
Brief summary
The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.
Detailed description
The study aims to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the deep structures of the fronto-striatal circuit involved in language processing. The research focuses on patients with neurodegenerative diseases who often suffer from communication deficits and impaired sentence comprehension. Participants will undergo a cross-over design consisting of a single session of active TIS directed at the striatum and a session of placebo stimulation. The stimulation will be administered in a randomized order. The duration of the stimulation is approximately 20 minutes. During the stimulation, participants will perform a sentence comprehension task. Resting-state fMRI measurements will be taken before and after the stimulation to evaluate offline effects on brain connectivity and potential neuroplasticity.
Interventions
Non-invasive brain interference stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.
DEVICEPlacebo / Sham TIS
Placebo stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.
Sponsors
Masaryk University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
60 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Possible or probable Mild Cognitive Impairment with Lewy Bodies (MCI-LB), in Parkinson's Disease (MCI-PD) or Amnestic Mild Cognitive Impairment (aMCI).
Exclusion criteria
* Any severe psychiatric disorder. * History of other neurological diseases affecting the central nervous system. * Severe head trauma. * Uncompensated internal or oncological disease. * Presence of MRI-incompatible metal in the body (e.g., pacemaker).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Task-Related Brain Activation | Immediately following the 20-minute stimulation session (approximately 0 to 30 minutes post-stimulation). | Assessment of the immediate offline effects of the prior stimulation on brain activation in language and fronto-striatal networks. This is measured using functional magnetic resonance imaging (fMRI) during an fMRI-adapted language task immediately after the stimulation session. The Blood Oxygen Level-Dependent (BOLD) signal acquired following active TIS will be compared to the signal acquired following placebo (sham) TIS. |
| Changes in Resting-State Functional Connectivity | Immediately following the 20-minute stimulation session (approximately 0 to 30 minutes post-stimulation). | Evaluation of short-term neuroplasticity and network-level changes induced by the stimulation. Resting-state functional magnetic resonance imaging (rs-fMRI) data acquired immediately after the active TIS session will be compared to rs-fMRI data acquired after the placebo (sham) TIS session to identify changes in functional connectivity between the targeted striatum and broader cortical language networks. |
| Behavioral Performance in Sentence Comprehension Task | During the approximately 20-minute stimulation intervention. | Evaluation of language processing measured by accuracy (number or percentage of correct responses) and reaction time (in milliseconds) during the Sentence Comprehension Task. This task is completed by the participant concurrently with the administration of either active Temporal Interference Stimulation (TIS) or placebo (sham) TIS outside of the MRI scanner. |
Countries
Czechia
Contacts
CONTACTĽubomíra Nováková, Ph.D.
Outcome results
None listed