Borderline Personality Disorder (BPD)
Conditions
Keywords
Psychotherapy, DBT, therapeutic alliance, depression, cognitive function, impulsivity, suicide risk, BDNF, NFκB, SOD, BPD, Supportive psychotherapy
Brief summary
In the context of therapy for Borderline Personality Disorder, our department had conduct a study titled "The Effectiveness of Dialectical Behavioral Group Psychotherapy Compared to Supportive Individual Psychotherapy in Patients with Borderline Personality Disorder: A Study of Therapeutic Alliance, Depression, Cognitive Function, Impulsivity, Suicide Risk, BDNF Levels, NFkB Levels, SOD Levels."
Detailed description
Psychotherapy for Borderline Personality Disorder provided weekly for 13 weeks. Patients have given a logbooks. Researchers monitored patients weekly by telephone and monitor them during outpatient visits in the second, fourth, sixth, eighth, and twelfth weeks. Blood samples were taken before and 13 weeks after treatment. During the study, patients were advised not to consume any medications or herbal remedies outside of those prescribed by the doctor and recorded in the study.
Interventions
BEHAVIORALDBT group psychotherapy
13 weeks, one session per week. Each week, one 2-hour dialectical therapy group session for 5 patients in a group.
BEHAVIORALSupportive Psychotherapy
13 weeks, one session per week. Each week, one 30-minute session of individual supportive psychotherapy
Sponsors
Natalia Dewi Wardani, MD
Faculty of Medicine University of Diponegoro, Indonesia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Masking description
Each patient was assigned an identification number, and the researcher who drew blood did not know whether the patient was in the treatment group or the control group
Intervention model description
Randomization was performed to assign the research sample to either the treatment group (Dialectical Behavior Therapy Group) or the control group (Supportive Individual Psychotherapy).
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Aged 18-60 years old * Diagnosed with Borderline Personality Disorder based on the Structured Clinical Interview for DSM-V Axis II Disorders (SCID-II) * Junior high school education or higher * Patients willing to participate in the study.
Exclusion criteria
* Taking immunosuppressive drugs since one week before the study. * Based on interviews or medical records, there is no history of post-stroke, epilepsy, or diabetes mellitus.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Therapeutic Alliances with California Psychotherapy Alliance Scales (CALPAS) | 13 weeks | California Psychotherapy Alliance Scales (CALPAS) score. A higher CALPAS (California Psychotherapy Alliance Scale) score indicates a stronger, more positive therapeutic alliance between a patient and their therapist. The California Psychotherapy Alliance Scale (CALPAS) uses a 7-point Likert scale for its 24 items, ranging from 1 ("not at all") to 7 ("very much so"). Minimum score 24 and maximum score 168. |
| Depression with GRID Hamilton Depression Rating Scale (GRID HAM-D) | 13 weeks | GRID Hamilton Depression Rating Scale (GRID HAM-D) score, interval, higher total scores indicating greater severity of depression. Minimum Score: 0 (No depression) Maximum Score: 52 (Severe depression) |
| cognitive function with Montreal Cognitive Assesment versi Indonesia (MoCA-Ina) | 13 weeks | Montreal Cognitive Assesment Indonesian version (MoCA-Ina) score, interval. A 30-point screening tool validated to detect mild cognitive impairment (MCI) and dementia in Indonesia, with a score of 26 or higher considered normal. |
| impulsivity with Barrat Impulsiveness Scale (BIS11) | 13 weeks | Barrat Impulsiveness Scale (BIS11) score, interval, Higher scores indicate greater impulsivity, with 30-51 indicating low, 52-71 average, and 72+ high impulsivity. |
| Suicide Risk with Columbia Suicide Severity Rating Scale (CSSRS) | 13 weeks | Columbia Suicide Severity Rating Scale (CSSRS) score, interval, Any "Yes" answer to behavior or ideation requires further clinical assessment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| NFkB Levels in ng/ml | 13 weeks | ratio scale, nanogram/mililiter |
| BDNF level in pg/ml | 13 weeks | BDNF level in picogram/mililiter, ratio scale |
| SOD levels in ng/ml | 13 weeks | ratio scale, nanogram/mililiter |
Countries
Indonesia
Contacts
STUDY_CHAIRM.I. Widiastuti MIW Widiastuti, Prof. dr.PAK(K), Sp.S(K), M.Sc
Medical Faculty Diponegoro University
Outcome results
None listed