Anterior Segment Diseases
Conditions
Keywords
Anterior Segment Diseases, Artificial Intelligence
Brief summary
Accurate and comprehensive interpretation of anterior segment diseases from slit-lamp and smartphone photographs remains a clinical challenge due to the limited specificity and structure of existing Artificial Intelligence tools. The purpose of this international, multicenter clinical trial is to developed and validated an agent-based framework that integrates vision-language models and large language models to enhance the diagnostic workflow of anterior segment diseases.
Interventions
Multimodal Vision-language Model for Multi-task Diagnosis and Triage Suggestions of Ophthalmic Diseases Patients presenting with complaints of anterior segment diseases first complete a slit-lamp examination or take a mobile phone eye photograph. A multimodal vision-language model uses patient-related images (such as selfies and eye exam photos) to make an intelligent diagnosis. The diagnosis is kept private. The patient then seeks medical attention and undergoes a clinical examination by an experienced clinician. A second experienced clinician then reviews the clinical diagnosis. If the diagnosis agrees, it is considered the gold standard. If there is a discrepancy in the diagnosis, the consensus between the two clinicians is used as the gold standard.
Sponsors
Study design
Eligibility
Inclusion criteria
1. Informed consent obtained; 2. Participants should be sufficiently able to read, write, and understand Chinese or English; 3. For normal participants: individuals should have no concerns related to their eyes. 4. For participants with eye-related chief complaints: individuals should have specific concerns or issues related to their eyes.
Exclusion criteria
1. Incomplete clinical data to support final diagnosis; 2. Patients who, in the opinion of the attending physician or clinical study staff, are too medically unstable to participate in the study safely.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic accuracy of multimodal vision-language model. | from July 2025 to September 2025 | For each patient, the diagnoses generated by the multimodal vision-language model and the clinical diagnosis provided by skilled clinicians were documented and compared. Consistency between the two diagnoses indicates the program's precision in clinical practice. |
Countries
China