Italian Group of Regenerative and Occlusive Worldwide-used Techniques of Hepatic Hypertrophy

Italian Group of Regenerative and Occlusive Worldwide-used Techniques of Hepatic Hypertrophy - IGROWtoh

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07445412

Acronym

I-GROWtoh

Enrollment

2000

Registered

2026-03-03

Start date

2024-10-22

Completion date

2040-04-01

Last updated

2026-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cancer (Primary and Metastatic), Liver Hypertrophy, Liver Resection, Liver Tumours

Brief summary

The goal of this national mutlticenter observational study is to learn and describe trends over time in the use of techniques for inducing hepatic hypertrophy in Italy. Patients will be treated according to the current clinical practice of the participating centers and will be observed from the moment of recruitment and throughout their stay. Information on vital status will be collected, as far as possible, for up to 5 years after surgery in order to record any events that occur in a timely manner. There are also plans to retrospectively collect data on patients who underwent hypertrophic techniques in the previous 10 years, in order to establish a historical cohort for each center that can be used for comparison with the prospective cohort.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients aged 18 or older * Obtaining informed consent * Patients with liver neoplasia (benign or malignant) and with a future liver remnant volume deemed insufficient (\<20%-40%) by the local multidisciplinary team

Exclusion criteria

* pregnant or breastfeeding woman

Design outcomes

Primary

Measure	Time frame
Describe the temporal trends in the use of techniques for inducing hepatic hypertrophy in Italy	through study completion, an average of 1 year
compare the techniques used in terms of function and volumetric hypertrophy	through study completion, an average of 1 year
compare the techniques used in terms of drop-out	through study completion, an average of 1 year
compare the techniques used in terms of 90-day mortality	through study completion, an average of 1 year
compare the techniques used in terms of long-term survival	through study completion, an average of 1 year
compare the techniques used in terms of disease-free survival	through study completion, an average of 1 year

Countries

Italy

Contacts

CONTACTElio Jovine, MD

elio.jovine@aosp.bo.it+39 3356468200

CONTACTMatteo Serenari, MD

matteo.serenari@aosp.bo.it+39 3289277643

PRINCIPAL_INVESTIGATORElio Jovine, MD

IRCCS Policlinico di Sant'Orsola - Malpighi (Bologna, Italy)

Outcome results