10-Year Survival After Acute Hip Fracture in Patients With Preclinical/Clinical Alzheimer Pathology

10-Year Follow-up of Mortality in Patients With Acute Hip Fractures: Associations With Pre-Alzheimer's/Alzheimer's Disease and Cerebrospinal Fluid Biomarkers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07443566

Enrollment

404

Registered

2026-03-02

Start date

2013-10-01

Completion date

2015-06-01

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer s Disease, Dementia, Hip Fractures (ICD-10 72.01-72.2)

Brief summary

This study is a 10-year follow-up of a previously enrolled cohort of patients who underwent surgery for acute hip fracture with spinal anesthesia and had pre-fracture cognitive status assessed (Clinical Dementia Rating, CDR) and cerebrospinal fluid (CSF) biomarkers related to Alzheimer's disease measured (e.g., Aβ42/Aβ40 ratio, total tau, phosphorylated tau). The primary aim is to determine long-term survival at 10 years after index hip fracture surgery and to evaluate whether baseline cognitive status and/or Alzheimer-type CSF biomarker profiles are associated with long-term mortality.

Detailed description

Participants were originally included during admission for acute hip fracture (October 2013-June 2015) at Sahlgrenska University Hospital, Mölndal, Sweden, and underwent lumbar CSF sampling at spinal anesthesia induction. Cognitive status prior to the fracture was assessed using CDR. Mortality will be ascertained through Swedish national registries. The follow-up extends survival assessment to approximately 10 years after surgery. Analyses will compare survival across baseline cognitive status categories and biomarker-defined groups (e.g., normal vs abnormal Aβ42/Aβ40 ratio), and may adjust for baseline covariates (e.g., age, sex, ASA class / hip fracture risk scores if available from original dataset).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* Participant enrolled in the original acute hip fracture cohort (index surgery during Oct 2013-Jun 2015 at Sahlgrenska University Hospital, Mölndal) * Available personal identity number enabling linkage to Swedish registries * Baseline cognitive assessment (CDR) and/or CSF biomarker data available from the index admission

Exclusion criteria

Missing linkage information preventing ascertainment of vital status \-

Design outcomes

Primary

Measure	Time frame
All-cause mortality / survival at 10 years after index hip fracture surgery	up to 10 years post-surgery

Secondary

Measure	Time frame	Description
Time to death from date of surgery (survival time)	10 years ( up to 10 years post-surgery)	All-cause mortality /survival at 10 years after index hip fracture surgery
Association between baseline CDR category and long-term mortality	up to 10 years	—

Countries

Sweden

Outcome results