Incidence of Postoperative Diaphragmatic Dysfunction in Pregnant Women With Preeclampsia

Incidence of Postoperative Diaphragmatic Dysfunction in Pregnant Women With Preeclampsia With Severe Features Undergoing Cesarean Delivery: A Prospective Observational Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07443345

Enrollment

Registered

2026-03-02

Start date

2026-03-09

Completion date

2026-12-31

Last updated

2026-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preecalmpsia

Keywords

preeclampsia, Diaphragmatic dysfunction

Brief summary

Preeclampsia with severe features remains a leading contributor to maternal morbidity and mortality, particularly in low- and middle-income countries. It is defined by hypertension and involvement of multiple organ systems, including renal, hepatic, hematologic, and neurologic pathways. The interplay of endothelial dysfunction, capillary leakage, and disrupted fluid balance in these patients increases their susceptibility to perioperative pulmonary complications. Although respiratory complications in preeclampsia are clinically significant, the true incidence of postoperative diaphragmatic dysfunction in women with severe disease is not well established. Existing literature largely emphasizes general respiratory failure, pulmonary edema, or the need for mechanical ventilation, rather than specifically evaluating diaphragmatic performance with objective methods such as ultrasound. The current study sought to determine the incidence and identify risk factors for postoperative diaphragmatic dysfunction in women with severe preeclampsia following cesarean delivery.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Patients with severe preeclampsia undergoing cesarean section * Gestational age \> 32 weeks

Exclusion criteria

* • Age \< 20 years. * Diabetic * Patients with neuromuscular diseases. * Patient refusal. * Contraindications to magnesium sulphate administration * Inability to obtain adequate ultrasound views

Design outcomes

Primary

Measure	Time frame	Description
The incidence of postoperative diaphragmatic dysfunction	Diaphragmatic excursion is measured before and 24 hours after surgery.	diaphragmatic dysfunction is defined as a mean diaphragmatic excursion of less than 10 mm

Secondary

Measure	Time frame	Description
Risk factors associated with postoperative diaphragmatic dysfunction	24 hours after surgery	Regression analysis to detect risk factors
Percentage of change in DE	24 hours after surgery	Percentage of change in diaphragmatic excursion from baseline to 24 hours after surgery

Countries

Egypt

Contacts

CONTACTMina Adolf Helmy, MD

minaadolf1988@cu.edu.eg01275716942

Outcome results