The Factors Influencing the Success of Redo Surgery and Anal Function for Anastomosis Failure or Local Tumor Recurrence

A Multicenter Retrospective Study in China: the Factors Influencing the Success of Redo Surgery and Anal Function for Anastomosis Failure or Local Tumor Recurrence

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07440888

Enrollment

143

Registered

2026-02-27

Start date

2006-03-01

Completion date

2023-12-31

Last updated

2026-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anastomosis, Leaking, Colo-rectal Cancer

Brief summary

To analyze the influencing factors of the success of redo surgery due to anastomotic fistula or anastomotic recurrence after rectal cancer surgery and to evaluate the anal function of patients

Detailed description

Redo surgery is a critical salvage strategy for anastomotic complications or local recurrence following rectal cancer resection. Despite technical feasibility, functional outcomes remain suboptimal. This study evaluated intestinal continuity restoration and anal function recovery after redo surgery, alongside prognostic factors influencing outcomes. A retrospective multicenter study analyzed 143 patients undergoing redo surgery (2015-2023) for anastomotic failure or local recurrence. Primary endpoints included anatomical restoration of intestinal continuity, while secondary endpoints assessed functional outcomes using the LARS score.

Interventions

PROCEDUREredo surgery

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Prior curative resection for primary colorectal adenocarcinoma. * Subsequent reoperation for anastomotic failure or locoregional recurrence. * Absence of absolute contraindications to reoperative surgery.

Exclusion criteria

* Primary tumors located proximal to the sigmoid colon. * Radiologically confirmed distant metastases. * Presence of a permanent stoma at the time of questionnaire administration. * Insufficient literacy or cognitive function to complete study-related -questionnaires.

Design outcomes

Primary

Measure	Time frame
Whether postoperative patients with rectal cancer can restore intestinal continuity, that is, defecate through the anus	During the follow-up period, at least two years after rectal cancer surgery

Secondary

Measure	Time frame
Low Anterior Rectal Syndrome (LARS) Score of patients restoring intestinal continuity	During the follow-up period, at least one year has passed since the intestinal continuity was restored

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 28, 2026