Free Gingival Graft
Conditions
Keywords
Concentrated Growth Factor, Advanced Platelet-Rich Fibrin
Brief summary
The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting.
Detailed description
The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting. Fourty-five patients who underwent FGG harvesting were randomly assigned to three groups: (1) control group (n=15), receiving only a sterile gelatin sponge; (2) A-PRF group (n=15), receiving A-PRF clot membranes; and (3) CGF group (n=15), receiving CGF clot membranes at the donor site. The epithelization rate, color match, and sensation scores of the palatal wound were assessed at 1, 2, 3, and 4 weeks postoperatively. Pain levels, analgesic consumption, and bleeding time were self-reported by patients for the first 7 days of healing.
Interventions
PROCEDUREAdvanced platelet-rich fibrin
Advanced platelet-rich fibrin membranes and free gingival graft
PROCEDUREConcentrated growth factor
Concentrated growth factor membranes and free gingival graft
PROCEDURESterile gelatin sponge
Sterile gelatin sponge and free gingival graft
Sponsors
Ordu University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* at least 18 years old, * without systemic or periodontal diseases, * without medical contraindications to periodontal surgery * with full-mouth plaque control scores ≤ 20% * Gingival index scores ≤ 1
Exclusion criteria
* smoking habits, * diabetes mellitus, * pregnancy or lactation, * removable upper denture, * regular medication that could interpose the healing process, undergoing bisphosphonate therapy, history of radiation therapy of the jaws, and follow-up consults
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Epithelialization | Baseline | Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface |
| Pain perception | Baseline | Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain) |
Countries
Turkey (Türkiye)
Contacts
PRINCIPAL_INVESTIGATORFigen Öngöz Dede, Prof
Ordu Universitesi
Outcome results
None listed