Peeling of the Internal Limiting Membrane During Primary Vitrectomy for Retinal Detachment Repair

Effect of Peeling of the Internal Limiting Membrane on Vision Results After Primary Vitrectomy for Retinal Detachment Repair

Status

Terminated

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07438210

Enrollment

Registered

2026-02-27

Start date

2019-04-03

Completion date

2025-01-01

Last updated

2026-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinal Detachment

Brief summary

Primary vitrectomy for retinal detachment repair is one of the current methods for surgical treatment of retinal detachment. Additional peeling of the internal limiting membrane (ILM) was reported to successfully prevent development of epiretinal membranes after surgery. The aim of the study is to examine the effect of ILM-Peeling on visual acuity outcomes and on occurrence of postoperative epiretinal membranes.

Detailed description

Retinal detachment is a disorder, usually caused by peripheral retinal breaks, that leads to severe decrease in vision in untreated cases. Primary vitrectomy for retinal detachment repair is one of the current methods for surgical treatment of retinal detachment. Recent retrospective studies support the hypothesis, that peeling of the internal limiting membrane (ILM) is beneficial on postoperative visual acuity and lower rates of occurrence of epiretinal membranes after surgery \[Forlini et al. 2018\]. The aim of the study is to examine the effect of ILM-Peeling on visual acuity outcomes and on occurrence of postoperative epiretinal membranes.

Interventions

PROCEDUREILM-Peeling

during primary vitrectomy for retinal detachment repair additional ILM-Peeling is performed

PROCEDURENo Peeling

during primary vitrectomy for retinal detachment repair no additional ILM-Peeling is performed

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* retinal detachment * age: 18 or older * written informed consent for surgery and participation in the study prior to surgery

Exclusion criteria

* pregnancy (pregnancy test will be taken preoperatively in women of reproductive age)

Design outcomes

Primary

Measure	Time frame
visual acuity	from enrollment to the end of follow-up at 4 years after surgery

Secondary

Measure	Time frame
occurrence of epiretinal membranes	from enrollment to the follow-up at 4 years after surgery

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 16, 2026