Periodontitis, Chronic Prostatitis (CP), Urinary Tract Infections
Conditions
Brief summary
This randomized controlled clinical trial evaluates the impact of non-surgical periodontal therapy on systemic inflammatory markers in patients with chronic prostatitis or recurrent urinary tract infections. Emerging evidence suggests a possible association between periodontal inflammation and genitourinary conditions. A total of 60 male participants diagnosed with periodontitis and either chronic prostatitis or recurrent urinary tract infections were randomly assigned to one of three groups: non-surgical periodontal therapy, oral hygiene instruction only, or no periodontal treatment. The primary outcomes were changes in serum prostate-specific antigen (PSA) levels and the frequency of positive urine cultures over a 120-day follow-up period. The study aims to investigate whether periodontal treatment may reduce systemic inflammatory burden and improve genitourinary clinical parameters.
Detailed description
This parallel-group randomized clinical trial was conducted at a university healthcare center. Eligible participants were adult male patients diagnosed with periodontitis and chronic prostatitis (NIH category III) or recurrent urinary tract infections. Participants were randomly allocated to receive full-mouth scaling and root planing combined with oral hygiene instruction, oral hygiene instruction alone, or no periodontal intervention during the study period. Clinical periodontal parameters, serum PSA levels, and microbiological urine cultures were assessed at baseline and at 120 days. Statistical analyses were performed to evaluate intergroup differences and longitudinal changes.
Interventions
PROCEDURENon-surgical periodontal therapy
Full-mouth scaling and root planing performed under local anesthesia using ultrasonic and hand instruments, completed within two sessions over a one-week period. Participants also received standardized oral hygiene instructions including tooth brushing technique and interdental cleaning guidance.
BEHAVIORALOral hygiene instruction
Standardized oral hygiene instructions including tooth brushing technique, use of interdental cleaning devices, and reinforcement of plaque control measures, without mechanical periodontal instrumentation.
Sponsors
University of Salamanca
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Masking description
Due to the nature of the intervention, blinding of participants and care providers was not feasible.
Intervention model description
Participants were randomly assigned in a parallel design to one of three groups: non-surgical periodontal therapy, oral hygiene instruction, or no periodontal treatment, with a 120-day follow-up period.
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Male participants aged 18 years or older * Diagnosis of chronic prostatitis (NIH category III) or recurrent urinary tract infections * Diagnosis of periodontitis according to the 2017 World Workshop classification * Ability to provide written informed consent
Exclusion criteria
* Antibiotic therapy within the previous 3 months * Systemic immunosuppressive disorders * History of prostate cancer * Ongoing periodontal treatment Severe systemic diseases affecting inflammatory status
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum prostate-specific antigen (PSA) levels | Baseline to 120 days | Difference in serum prostate-specific antigen (PSA) levels measured in ng/mL between baseline and 120 days after intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in frequency of positive urine cultures | Baseline to 120 days | Difference in the number of microbiologically confirmed urinary tract infections between baseline and 120 days. |
Countries
Spain
Outcome results
None listed