Chronic Kidney Disease
Conditions
Keywords
Nephrology, exercise, physical activity
Brief summary
This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control group
Interventions
OTHERExercise
All participants will be involved in the exercise training three times per week for 24 weeks: endurance exercise training, resistant exercise training
OTHERcontrol
outcome measures
Sponsors
Casa di Cura Dott. Pederzoli
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Signature of the informed consent * Patients with CKD stage 1 to 5 under conservative treatment * Patients undergoing chronic hemodialysis for at least 3 months * Age ≥ 18
Exclusion criteria
* Severe cardiovascular disease (NYHA class IV or hypertension class III) * TIA or myocardial ischemia within the last three months * Anatomical limitations * Health conditions detected during the stress test (CPET)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gait speed (6MWT) | through study completion, an average of 1 year | • Assess the effect of exercise on physical performance and quality of life on pa-tients with chronic kidney disease from stage 1 to end stage renal disease on maintenance haemodialysis or on conservative treatment |
| Physical performance (SPPB) | through study completion, an average of 1 year | — |
| Cardiopulmonary capacity (CPET) | through study completion, an average of 1 year | — |
| Lower limbs strength (1-RM) | through study completion, an average of 1 year | — |
| Maximum isometric strength of the upper limb (hand grip) | through study completion, an average of 1 year | — |
| Daily physical activity amount (IPAQ) | through study completion, an average of 1 year | — |
| Quality of life (SF36) | through study completion, an average of 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional status (24HR, FFQ) | through study completion, an average of 1 year |
| Body composition (DEXA, BIVA) | through study completion, an average of 1 year |
| Psychological and psychosocial conditions (BDI, MMSE) | through study completion, an average of 1 year |
| Hemodynamic and vascular functions (SV, CO, HR, FBF, FMD, sPLM) | through study completion, an average of 1 year |
| Muscular oxygen extraction (NIRS) | through study completion, an average of 1 year |
| Neuromuscular functions (MCV, RFD) | through study completion, an average of 1 year |
Countries
Italy
Outcome results
None listed