Hepatic Encephalopathy, Liver Cirrhosis, TIPS
Conditions
Keywords
cirrhosis, transjugular intrahepatic portosystemic shunt, hepatic encephalopathy, prognosis, nomogram
Brief summary
This study aims to develop a practical tool for identifying cirrhotic patients at high risk of hepatic encephalopathy following transjugular intrahepatic portosystemic shunt (TIPS) placement. A retrospective analysis will be conducted on medical records of 624 cirrhotic patients who underwent TIPS from 2011 to 2021. Statistical methods will be applied to screen preoperative routine indicators associated with post-TIPS hepatic encephalopathy risk. A predictive nomogram will be constructed incorporating the screened indicators to estimate individual preoperative risk. The predictive performance will be compared with conventional clinical scoring systems. This tool is intended to facilitate preoperative risk evaluation and targeted management of high-risk patients undergoing TIPS
Detailed description
Background: Transjugular intrahepatic portosystemic shunt (TIPS) is an important treatment for the complications of portal hypertension. However, hepatic encephalopathy remains a major complication after TIPS, and its independent risk factors are not fully elucidated. The purpose of this study is to investigate the independent risk factors of hepatic encephalopathy (HE) after TIPS in patients with liver cirrhosis, and to construct a nomogram model to identify high-risk patients before TIPS. Method: This retrospective study will include cirrhotic patients who underwent TIPS at the Second Affiliated Hospital of Chongqing Medical University between 2011 and 2021. Patients will be randomly split into training (70%) and validation (30%) cohorts. Predictors will be selected using LASSO regression with cross-validation and further analyzed via multivariable logistic regression to build a nomogram. Model performance will be evaluated and compared with conventional scores (MELD, MELD-Na, ALBI, FIPS). Result: To be reported after study completion. Conclusion: A nomogram based on routine preoperative variables is hypothesized to predict HE risk after TIPS. This study intends to provide a tool for preoperative risk stratification and individualized patient management. Keywords: cirrhosis; transjugular intrahepatic portosystemic shunt; hepatic encephalopathy; prognosis; nomogram
Interventions
None listed
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-80 years, regardless of gender * Diagnosis of decompensated cirrhosis meeting clinical guidelines * Complete preoperative baseline data available, with regular postoperative follow-up for at least 3 months to assess endpoint events * Absence of absolute contraindications for TIPS
Exclusion criteria
* Age \< 18 or \> 80 years * Non-cirrhotic portal hypertension * Hepatocellular carcinoma or other systemic malignancies * Severe cardiopulmonary disease * Prior liver transplantation or portosystemic shunt surgery * Death or liver transplantation within 30 days post-TIPS * Missing key baseline data or loss to follow-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of hepatic encephalopathy within 3 months after TIPS | 3-month follow-up after TIPS | The development of hepatic encephalopathy, diagnosed based on clinical assessment and medical records during follow-up outpatient visits or hospital readmissions within 3 months after the TIPS procedure. All HE cases in this study occurred within this period. |
Countries
China
Outcome results
None listed