PRF + Minocycline vs Arestin in Non-surgical Perio Therapy

Conditions

Non-surgical Periodontal Therapy

Keywords

Non-surgical periodontal therapy, Platelet-rich Fibrin, Minocycline, PRF

Brief summary

Periodontitis is a chronic, biofilm-modulated inflammatory disease characterized by microbial dysbiosis and a dysregulated host immune response, eventually resulting in the gradual breakdown of the periodontal attachment apparatus. While non-surgical periodontal therapy (NSPT) remains the first choice of treatment, its capability to completely resolve inflammation and pocketing in moderate disease severity may be limited, supporting the use of adjunctive antimicrobial or biologic interventions. Platelet-rich fibrin (PRF) and locally administered antibiotics, including minocycline, have individually shown clinical advantages; nonetheless, evidence assessing their combined utility remains unexplored. This split-mouth randomized controlled clinical trial (RCT) aims to compare the clinical efficacy of PRF combined with minocycline versus minocycline microspheres hydrochloride (Arestin) as adjuncts to NSPT in patients with Stage II or III, Grade A or B periodontitis.

Detailed description

Periodontitis is a chronic, biofilm-modulated inflammatory disease characterized by microbial dysbiosis and a dysregulated host immune response, eventually resulting in the gradual breakdown of the periodontal attachment apparatus. While non-surgical periodontal therapy (NSPT) remains the first choice of treatment, its capability to completely resolve inflammation and pocketing in moderate disease severity may be limited, supporting the use of adjunctive antimicrobial or biologic interventions. Platelet-rich fibrin (PRF) and locally administered antibiotics, including minocycline, have individually shown clinical advantages; nonetheless, evidence assessing their combined utility remains unexplored. This split-mouth randomized controlled clinical trial (RCT) aims to compare the clinical efficacy of PRF combined with minocycline versus minocycline microspheres hydrochloride (Arestin) as adjuncts to NSPT in patients with Stage II or III, Grade A or B periodontitis.

Related papers

No related papers found yet.

Interventions

DRUGArestin

Arestin evaluated as an adjunct to non-surgical therapy

BIOLOGICALPRF + M

PRF with Minocycline evaluated as an adjunct to non-surgical therapy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Masking description

Participants do not know which site is receiving which treatment.

Intervention model description

This will be a split-mouth study in which patients undergoing non-surgical periodontal therapy will be included. One interproximal site will be assigned to receive adjunctive Arestin while another site will be randomly assigned to receive platelet-rich Fibrin mixed with minocycline.

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Male and Female subjects requiring non-surgical periodontal therapy• No contraindications to periodontal treatment

Exclusion criteria

* previous periodontal treatment within the past 6 months; * local or systemic antibiotic treatment within the past 3 months; * diagnosis of Stage I/ or IV periodontitis; * poor oral hygiene defined as a full-mouth plaque score \>30%; * history of radiation or immunosuppressive therapy; * presence of neurologic disorders, major mechanical obstruction to mouth opening, or acute temporomandibular capsulitis; * systemic conditions that may compromise bone metabolism or wound healing such as metabolic bone disease, uncontrolled diabetes; * history of substance abuse such as drug or alcohol; or * current pregnancy, nursing, or planning pregnancy during the study period.

Design outcomes

Primary

Measure	Time frame	Description
Clinical Attachment Loss	6 months	Clinical Attachment Loss was measured utilizing a periodontal probe at six sites per tooth.
Probing Depths	6 months	Probing depths were recorded utilizing a periodontal probe at six sites per tooth.
Gingival Recession	6 months	Gingival Recession was measured utilizing a periodontal probe at six sites per tooth.

Countries

United States

Outcome results

None listed