Vitamin D Deficiency
Conditions
Keywords
Vitamin D Deficiency, Postural Stability, Balance Control, Neuromuscular Control, Surface Electromyography, Reflex Modulation, Bone Myoregulation Reflex, Standing Balance, Rehabilitation Research, Postural Sway
Brief summary
This observational study aims to investigate the relationship between vitamin D deficiency, postural stability, and neuromuscular control mechanisms in adults. The study will compare individuals with vitamin D deficiency and healthy controls. Participants will undergo a single-session evaluation including surface electromyography and postural stability assessments during standing tasks under different loading and vibration conditions. No invasive procedures, medications, or blood sampling will be performed. Previously obtained routine laboratory results will be used for vitamin D status. The study is designed to improve understanding of neuromuscular responses associated with vitamin D deficiency and to contribute to future rehabilitation strategies.
Detailed description
This single-center observational study is designed to evaluate postural stability and load-sensitive neuromuscular control mechanisms in adults with vitamin D deficiency. Participants will be divided into two groups based on their vitamin D status: individuals with vitamin D deficiency and healthy controls. Vitamin D levels will be determined using previously obtained routine laboratory test results. No additional blood sampling will be performed for this study. All participants will undergo a standardized assessment protocol in a single session. Surface electromyography will be used to record muscle activity during standing tasks under different postural and loading conditions. Measurements will be performed during single-leg and double-leg stance, with and without vibration stimulation. The procedures are non-invasive and do not involve any pharmacological intervention. Postural stability parameters and neuromuscular response variables will be analyzed and compared between groups. The primary objective is to identify potential differences in reflex modulation and postural control associated with vitamin D deficiency. The study aims to provide objective data on neuromuscular adaptations related to vitamin D status and to support future research in rehabilitation and balance training.
Interventions
None listed
Sponsors
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 20 to 40 years. * Ability to provide written informed consent. * Vitamin D deficiency group: serum 25-hydroxyvitamin D level \<10 ng/mL measured within the last 3 months (routine clinical testing). * Healthy control group: normal vitamin D status based on routine clinical testing within the last 3 months. * No use of vitamin D or calcium supplementation within the last 3 months.
Exclusion criteria
* Known metabolic bone disease other than vitamin D deficiency. * Neurological disorder (central or peripheral) or neuromuscular disease. * History of lower-limb surgery, fracture, or prosthesis affecting standing balance. * Vestibular disorder. * BMI \>30 kg/m2. * Active malignancy. * Severe psychiatric disorder. * Skin condition preventing placement of surface EMG electrodes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postural Stability Parameters | Single assessment session (baseline) | Postural stability parameters measured during single-leg and double-leg standing using force platform and surface electromyography, including postural sway and neuromuscular response variables. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neuromuscular Reflex and Muscle Activation Patterns | Single assessment session (baseline) | Surface electromyography-derived muscle activation and reflex modulation parameters recorded under different loading and vibration conditions. |
| Effect of Loading and Vibration on Postural Control | Single assessment session (baseline) | Changes in postural stability and neuromuscular responses under loaded and unloaded conditions with and without vibration. |
Countries
Turkey (Türkiye)
Contacts
CONTACTSelim Sezikli, MD
CONTACTIlhan Karacan, Prof.
PRINCIPAL_INVESTIGATORSelim Sezikli, MD
Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
Outcome results
None listed