Comparative Outcomes of Radiofrequency Ablation of Concealed and Manifest Accessory Pathways: a Single Center, Retrospective Observational Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07435181

Enrollment

220

Registered

2026-02-27

Start date

2026-04-01

Completion date

2027-07-01

Last updated

2026-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrioventricular Reentrant Tachycardias, Wolff-Parkinson-White (WPW) Syndrome

Keywords

Accessory pathway, Radiofrequency ablation, Wolff-Parkinson-White

Brief summary

The aim of this observational, retrospective study is to evaluate, comparatively, procedural outcomes of APs (Accessory pathway) ablation according to the conduction properties (i.e., manifest vs. concealed) and to assess both short- and long-term outcomes of RFA (RF ablation).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to 60 Years

Healthy volunteers

Inclusion criteria

1. Patients who consecutively underwent an electrophysiological (EP) study between 2005 and 2023 at San Raffaele Scientific Institute are included if they met one of the following criteria: Patients referred for EP study due to: * EITHER clinical suspicion of paroxysmal supraventricular tachycardia without prior documentation of ventricular pre-excitation and/or supraventricular arrhythmia (SVA) on 12-lead surface electrocardiogram, OR with electrocardiographic evidence of SVA, AND electrophysiological confirmation of atrioventricular re-entrant tachycardia (AVRT) as the arrhythmic mechanism. * Ventricular pre-excitation documented on serial 12-lead surface ECGs, with or without clinical episodes suggestive of AVRT, who underwent catheter ablation of the accessory pathway based on: The presence of high-risk electrophysiological features (e.g., short antegrade effective refractory period of the AP, rapid conduction during atrial fibrillation), or Induction of sustained AVRT during the EP study. 2. Aged between 5 to 60 years old

Exclusion criteria

1. Lack of pre-specified follow-up: only patients with at least 1 years follow-up ambulatory visit will be included in the study 2. REDO CA procedure

Design outcomes

Primary

Measure	Time frame
Acute procedural success	At the end of the index procedure

Secondary

Measure	Time frame
Procedural complexity	From the end of the index procedure to discharge and at the ambulatory follow-up visits
Durability of successful radiofrequency ablation	From the end of the index procedure to discharge and at the ambulatory follow-up visits

Contacts

CONTACTSimone Gulletta, MD

gulletta.simone@hsr.it02 2643 7484

CONTACTMarcello Cosenza, MD

cosenza.marcello@hsr.it02 2643 689

Outcome results