APPRAISE: Assessment of Pain and Posterior Synechiae Reduction With Atropine, an Investigation of Post-Surgical Eyes

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07434635

Acronym

APPRAISE

Enrollment

Registered

2026-02-25

Start date

2026-02-01

Completion date

2029-02-01

Last updated

2026-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Disorders

Keywords

atropine, eye surgery

Brief summary

The study will evaluate whether atropine eyedrops are beneficial when used after certain eye surgeries.

Detailed description

Atropine eyedrops are often used after certain eye surgeries. This study will compare several outcomes following surgery in patients either using or not using this treatment.

Interventions

DRUGAtropine 1%

Subtraction of atropine eyedrops from post-operative treatment regimen

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient undergoing vitrectomy surgery * able to give informed consent

Exclusion criteria

* post-operative eyedrop regimens that include topical non steroidal anti-inflammatory medications * subjects with altered post-operative eyedrop schedule for enhanced inflammation control * documented allergy to atropine

Design outcomes

Primary

Measure	Time frame	Description
Pain score on the Visual Analog Scale (VAS)	1 month	Whether atropine use impacts post-operative pain score on the standard Visual Analog Scale (VAS)

Secondary

Measure	Time frame	Description
Anterior chamber inflammation (aqueous cell and flare)	1 month	Whether atropine impacts the occurrence of post-operative inflammation, quantified as aqueous cell and flare, using the Standardization of Uveitis Nomenclature (SUN) Criteria
Cystoid macular edema detected by optical coherence tomography	1 month	Whether atropine impacts the occurrence of cystoid macular edema after surgery, detected by optical coherence tomography scanning of the retina
Time to visual recovery	1 month	Whether atropine impacts the time to visual recovery
Intraocular pressure	1 month	Whether atropine impacts intraocular pressure after surgery
Posterior synechiae formation	1 month	Presence or absence of posterior synechiae assessed by slit lamp examination at post-operative visits

Countries

United States

Contacts

CONTACTJay Stewart, MD

eyestudy@ucsf.edu415-353-9635

PRINCIPAL_INVESTIGATORJay Stewart, MD

University of California, San Francisco

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 27, 2026