Health Adult Subjects
Conditions
Keywords
concurrent TMS/fNIRS, prefrontal cortex, stress
Brief summary
The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS) induces immediate changes in prefrontal excitability in healthy individuals, compared to sham stimulation. In this randomized, sham-controlled trial, investigators will assess several psychological measures-including the Perceived Stress Scale and the Coping Inventory for Stressful Situations-to explore how stress levels and coping strategies relate to immediate prefrontal cortex (PFC) activity changes following TBS.
Interventions
DEVICETranscranial Magnetic Stimulation
sham stimulation protocols is to mimic the sensations experienced by participants during active stimulation, without stimulating the brain
Sponsors
The Hong Kong Polytechnic University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-60 years old;
Exclusion criteria
* a family history of psychiatric disorders; * history of or currently diagnosed neuropsychiatric conditions; * history of or active systemic illnesses such as cancer, epilepsy, diabetes, hypertension, or other medical conditions; * contraindications to transcranial magnetic stimulation (TMS); * any prior exposure to brain stimulation procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| iTBS induced prefrontal cortex activity and connectivity | 3 minutes before, during, and after the stimulation |
Secondary
| Measure | Time frame |
|---|---|
| perceived stress scale | the same day before conducting the experiment |
| coping inventory for stressful situations | the same day before conducting the experiment |
Countries
China
Outcome results
None listed