Parasternal Block Added to Serratus Anterior Plane Block in Breast Reduction Surgery

The Effect of Adding a Parasternal Intercostal Plane Block to a Serratus Anterior Plane Block on Postoperative Opioid Consumption in Breast Reduction Surgery

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07432256

Enrollment

Registered

2026-02-25

Start date

2024-05-01

Completion date

2025-12-01

Last updated

2026-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Reduction, Postoperative Pain, Opioid Consumption

Keywords

serratus anterior plane block, parasternal intercostal plane block, breast reduction surgery, pain management, postoperative pain, QoR-15

Brief summary

This study aims to evaluate the effect of adding a Superficial Parasternal Intercostal Plane Block (PIPB) to the Serratus Anterior Plane Block (SAPB) on postoperative pain control in patients undergoing breast reduction surgery under general anesthesia. Effective postoperative analgesia is essential to reduce opioid consumption and improve recovery. All patients will receive standard general anesthesia. Patients will be allocated into three groups: a control group receiving no regional block, a group receiving SAPB alone, and a group receiving SAPB combined with PIPB. The primary outcome of the study is total opioid consumption within the first 24 hours after surgery. Secondary outcomes include postoperative pain scores, Quality of Recovery-15 (QoR-15) scores, and intraoperative remifentanil consumption. The study aims to determine whether SAPB reduces postoperative opioid requirements compared to no block, and whether adding PIPB provides additional analgesic benefit by blocking the anterior cutaneous branches of the intercostal nerves. The findings may contribute to improving multimodal analgesia strategies in breast surgery.

Interventions

PROCEDURESerratus Anterior Plane Block (SAPB)

injection local anesthetic between 5th rib and serratus anterior muscle

PROCEDURESerratus Anterior Plane Block (SAPB) and parasternal intercostal plane block

both injection local anesthetic between 5th rib and serratus anterior muscle at midaxillary line and between 4th costal cartilage and pectoralis major muscle at next to the sternum

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Female patients aged 18-65 years * Scheduled for elective breast reduction surgery under general anesthesia * American Society of Anesthesiologists (ASA) physical status I-III * Ability to understand the study and provide written informed consent

Exclusion criteria

* Patient refusal * Known allergy to local anesthetics * Coagulopathy or ongoing anticoagulant therapy * Infection at the block site * Chronic opioid use or opioid dependence * Severe hepatic or renal insufficiency * Pregnancy or breastfeeding

Design outcomes

Primary

Measure	Time frame	Description
Total postoperative opioid consumption in the first 24 hours	First 24 hours after surgery	Total opioid consumption during the first 24 postoperative hours will be recorded and compared between the study groups.

Secondary

Measure	Time frame	Description
Quality of recovery by using QoR-15 questionnaire	postoperative 24th hour	—
Pain Scores	postoperative 0, 1, 2, 6, 12, 24 th hour	using NRS Scale

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 27, 2026