Carotis Intima-media Thickness, Chronic Kidney Disease, Geriatrics
Conditions
Keywords
geriatrics, chronic kidney disease, soluble vascular endothelial cadherin, FGF-23
Brief summary
Brief summary template The goal of this clinical trial is to assess endothelial dysfunction in geriatric non-dialysis CKD patients. The main questions it aims to answer are: • In geriatric non-dialysis CKD patients, the study aimed to demonstrate the relationship between soluble vascular endothelial cadherin and fibroblast growth factor-23 levels, which are indicators of endothelial dysfunction-and therefore a possible cardiovascular risk factor-using measurement methods such as ultrasonographic carotid intima-media thickness, flow-mediated dilation, and nailfold capillaroscopy. Participants will have measurement of; * ultrasonographic carotid intima-media thickness, * flow-mediated dilation, * nailfold capillaroscopy * venous blood sampling * Visit the clinic once,
Detailed description
In this single-center study, we aimed to evaluate endothelial dysfunction, the leading cause of mortality in geriatric CKD patients. We kept patient exclusion criteria strict and considered it more rational to conduct this study in a patient group requiring proactive intervention by excluding patients with 'known' cardiovascular disease. For this purpose, we used some non-invasive parameters known in the literature (ultrasonographic measurement of carotid intima-media thickness, nailfold capillaroscopy, flow-mediated dilation). We also planned to measure serum sVE Cadherin levels, which have not been clearly evaluated in geriatric CKD patients before, as well as serum FGF23 levels. We also planned to evaluate the relationship and correlation of these different parameters with other standard biochemical and anthropometric measurements. Patient recruitment for the study took place between May 12, 2023, and September 11, 2023. We followed up for mortality for approximately 2.3 years.
Interventions
DIAGNOSTIC_TESTUltrasonographic and Capillary Measurements
All measurements will be applied to the entire patient group.
Sponsors
Muğla Sıtkı Koçman University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with CKD who are not receiving RRT and those aged 65 and over
Exclusion criteria
* Patients under 65 years of age * history of coronary artery disease * history of peripheral artery disease * atrial fibrillation * heart failure * active immunosuppressive use * active infection * history of active malignancy * history of cerebrovascular event (ischemic/hemorrhagic) * Raynaud's phenomenon * renal transplant patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of serum sVE cadherin level and other measurements | Approximately 122 days were sufficient for patient recruitment for the study. After patient recruitment was completed, we followed the patients for approximately 844 days, monitoring their survival/death status. | To investigate the relationship between sVE cadherin levels and ultrasonographic carotid intima-media thickness (CIMT), flow-mediated dilation(FMD), nailfold capillaroscopy(NC) test results measured in patients. |
| Distribution of sVE cadherin levels in the patient group | Approximately 122 days were sufficient for patient recruitment for the study. After patient recruitment was completed, we followed the patients for approximately 844 days, monitoring their survival/death status. | sVE cadherin levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | After patient recruitment was completed, we followed the patients for approximately 844 days, monitoring their survival/death status. | Evaluation of those who died and those who survived after approximately over 2 years. |
Countries
Turkey (Türkiye)
Contacts
PRINCIPAL_INVESTIGATORAlper Alp, Assoc Prof,MD
Muğla Sıtkı Koçman University
Outcome results
None listed