Appendectomy
Conditions
Keywords
Analgesia, Bupivacaine, Open Appendectomy
Brief summary
To compare the clinical outcomes of intraperitoneal bupivacaine instillation vs placebo as preemptive analgesia in patients undergoing open appendectomy
Interventions
DRUGBupivacain
Bupivacaine with 0.25% of concentration at the end of the operation intraperitoneally.
OTHERNormal Saline
10ml of Normal Saline at the end of the operation intraperitoneally.
Sponsors
Sardar Umer Rehman
Services Institute of Medical Sciences, Pakistan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients presenting to the emergency department undergoing open appendectomy.
Exclusion criteria
* Patients undergoing interval appendectomy or having perforated appendix as evident by examination (abdominal tenderness/ fever) and USG findings (presence of abscess, fluid collection, or free air). * Uncontrolled medical disease (DM: BSL \>200mg/dl, HTN: BP \>140/90) * History of chronic kidney or liver disease/ psychiatric illness/ Active peptic ulcer disease (as determined on history and medical records) * Alcoholics * History of chronic pain or patients on analgesic medications * Pregnant females * History of allergy to bupivacaine/ ketorolac as determined on history * Children, Adolescents and patients with mental illness.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post operative pain | 24 hours | Intensity of post operative pain by using visual analogue score and frequency of postoperative rescue analgesics if required after instillation of bupivacaine and placebo in both groups. Both outcomes will be noted at different intervals i.e. 2, 6, 12 and 24 hours postoperatively for comparison as mentioned. |
Countries
Pakistan
Contacts
CONTACTDr Sardar Umar Rehman, MBBS
Outcome results
None listed