Regenerative Endodontic Procedures
Conditions
Keywords
Immature permanent teeth
Brief summary
This randomized clinical trial evaluated the clinical and radiographic outcomes of regenerative endodontic procedures performed using different irrigation activation protocols in immature permanent maxillary anterior teeth. Thirty patients were randomly assigned into three groups according to the use of laser-activated irrigation and number of visits. Clinical and cone beam computed tomographic (CBCT) outcomes were assessed over a 12-month follow-up period.
Detailed description
Thirty patients aged 9-25 years with non-vital immature permanent maxillary anterior teeth were included. Patients were randomly allocated into three equal groups based on the irrigation activation technique and number of visits. Regenerative endodontic procedures were performed following standardized protocols. Clinical evaluations were conducted at multiple follow-up intervals, while radiographic assessments using CBCT were performed at baseline, 6, and 12 months to evaluate root development and periapical healing.
Interventions
PROCEDURERegenerative Endodontic Procedure
Regenerative endodontic procedure performed using sodium hypochlorite irrigation, intracanal double antibiotic paste, platelet-rich fibrin scaffold, and bioceramic coronal barrier according to a standardized clinical protocol.
PROCEDURELaser-Activated Irrigation
Irrigation activation using an 810-nm diode laser with a power of 1 W, applied for three cycles of 15 seconds with 15-second intervals, performed 1 mm short of the working length.
Sponsors
Ahmed Ibrahim Salim
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
9 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
* Non-vital immature permanent maxillary anterior teeth due to trauma or caries * Incomplete root formation with apical foramen \> 1 mm * Medically healthy patients
Exclusion criteria
* Allergy to medications used in the study Teeth requiring post and core restorations Periodontal pockets \> 4 mm Apical foramen \< 1 mm Periapical radiolucency \> 10 mm Internal or external root resorption History of major systemic surgeries (e.g., cardiac surgery, kidney transplantation, hemodialysis)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Success Rate at 12 Months | 12 months | Clinical success defined as the absence of pain, tenderness to percussion, swelling, or sinus tract, assessed through standardized clinical examination. The outcome will be reported as the number and percentage of treated teeth demonstrating clinical success. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Root Length Measured by CBCT | Baseline, 6 months, 12 months | Root length will be measured in millimeters (mm) using cone beam computed tomography (CBCT) imaging with a slice thickness of 0.5 mm, voxel size of 0.5 mm, and exposure parameters of 90 kV and 11 mA. Measurements will be obtained using OnDemand 3D software. The change in root length from baseline to 6 and 12 months will be calculated. |
| Change in Root Canal Width Measured by CBCT | Baseline, 6 months, 12 months | Root canal width will be measured in millimeters (mm) using CBCT imaging and OnDemand 3D software. |
| Change in Apical Diameter Measured by CBCT | Baseline, 6 months, 12 months | Periapical lesion size will be measured in millimeters (mm) using CBCT imaging and OnDemand 3D software. The reduction in lesion size from baseline to 6 and 12 months will be calculated. |
| Change in Periapical Lesion Size Measured by CBCT | Baseline, 6 months, 12 months | Periapical lesion size will be measured in millimeters (mm) using CBCT imaging and OnDemand 3D software. |
Countries
Egypt
Contacts
STUDY_DIRECTORAbeer M Darrag
Professor of Endodontics
Outcome results
None listed